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How can I find funding opportunities (RFAs, RFPs and PAs)?
What do I need to know before submitting a clinical research application?
Am I a new investigator and what if this is my first NIH application?
Which NHLBI staff can help me?
Is my study considered clinical research?
Is my study observational or interventional?
What is the best award mechanism for my clinical research proposal?
What if my project exceeds $500,000 in direct costs in any given year?
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What must I include in "Protection of Human Subjects"?
How and when do I submit my application?

Glossary Box


Research Project Grant

On this page:


Research Project Grants (RPGsGlossary Link) are awarded to institutions on behalf of a principal investigator to facilitate pursuit of a scientific focus or objective in the area of the investigator's interest and competence. Grants can be  awarded for single center or multicenter projects. (Guidelines can be found at  Institutional sponsorship assures the NIH that the institution will provide facilities necessary to accomplish the research and will be accountable for the grant funds. Applications are accepted for health-related research and development in all areas within the scope of NHLBI's mission.


In general, any organization is eligible to apply for regular NIH research grants, and unsolicited applications are welcome. The applicant is the research organization, although a principal investigator (PIGlossary Link) writes the research proposal; and if a grant is awarded, the grantee is the applicant organization. Applications may be submitted by domestic or foreign for-profit and non-profit organizations, public and private, such as universities, colleges, hospitals, laboratories, units of State and local governments, and eligible agencies of the Federal government. Racial/ethnic minority individuals, women, and persons with disabilities are encouraged to apply as principal investigators. The NHLBI encourages applications from new investigators.

Scope of Support

The project period is for up to five years. Applications requesting greater than $500,000Glossary Link in direct costsGlossary Link for any year must contact NHLBI staff before submitting the application. Complete information about consideration of unsolicited applications requesting more than $500,000 direct costs can be found at NHLBI research project (R01) support is renewable through the submission of competing continuation applications.

How to Apply

Applications requesting $250,000 or less per year in direct costsGlossary Link must follow Modular Grant Application Procedures. A full description of the Modular Grant application may be found at: 

Additional information can be found at:

When to Apply

New Applications February 5, June 5, October 5
Competing Continuations March 5, July 5, November 5


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