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Division of Cardiovascular Diseases Strategic Plan
In 2006, The National Heart, Lung, and Blood Institute (NHLBI) initiated a process to develop strategies for facilitating research, training, and application of research advances in areas related to its mission. This process began with the convening of 23 Working Groups. More than 600 experts from around the nation were invited to attend and asked to provide the NHLBI with recommendations. These initial meetings resulted in “Level One Final Reports”, and their recommendations were consolidated into a final report. Following a period of modification based on public comment, the report was published as the NHLBI Strategic Plan: Shaping the Future of Research. The NHLBI Strategic Plan, as well as the 23 Level One Final Reports, can be accessed from the NHLBI Public Site, at http://www.nhlbi.nih.gov. The NHLBI Strategic Plan is intended to guide the NHLBI’s scientific direction for the next five to ten years and will be updated periodically as implementation/progress proceeds.
The NHLBI Strategic Plan encompasses 3 goals and 8 strategies for achieving them. These are broad and cross-cutting, providing themes and approaches that are applicable across the spectrum of priorities for research and training related to cardiovascular (CV), lung, and blood diseases, and sleep disorders. The challenge now turns to implementing these strategies.
The NHLBI Division of Cardiovascular Diseases (DCVD) provides leadership for basic, translational, and clinical extramural research in the area of CV health and disease. DCVD staff has embarked on implementing the strategies outlined in the NHLBI Strategic Plan by defining a series of goals, related to specific clinical problems, disease states, enabling technologies, research methodologies, and training needs. These 35 goals for research and training accomplishments over approximately the next 5 years constitute the DCVD Strategic Plan. They were derived principally from the Level One Final Report recommendations germane to the DCVD mission (see below) as well as from other workshops and working groups participated in by the scientific and clinical community.
The DCVD Strategic Plan is not intended to supplant the judgment and initiative of individual investigators. Over 70 percent of the support provided through the DCVD is directed toward investigator-initiated research. The research community is already achieving progress toward many of the goals in this document. As we implement the DCVD Strategic Plan, we intend to identify and prioritize those research areas that would benefit most from NHLBI stimulation and support.
The DCVD provides leadership for a national and international extramural program in cardiovascular diseases that integrates basic science and clinical research, including translational research, networks, and multicenter clinical trials. It designs, conducts, supports, and oversees research on the causes, prevention, and treatment of diseases and disorders such as atherothrombosis, coronary artery disease, myocardial infarction and ischemia, heart failure, arrhythmia, sudden cardiac death, adult and pediatric congenital heart disease, CV complications of diabetes and obesity, and hypertension. It also supports and oversees research in vascular medicine and biology, and valvular, cerebral, renal, peripheral, and other CV disorders. The DCVD fosters biotechnological research in genomics, proteomics, nanotechnology, imaging, device development, cell- and tissue-based therapeutics, and gene therapy and in their uses as they relate to CVD. It also supports training and career development programs in CV research at all educational levels from high school students to academic faculty, including programs for individuals from diverse populations.
This document is organized into 3 sets of goals related to 1) enabling technologies and methodologies, 2) clinical problems or disease states, and 3) research training and career development. Each goal is responsive to recommendations from one or more Level One Final Reports and/or recent specific workshops or working groups. Each amplifies one or more NHLBI Strategic Plan goals to the level of a specific clinical problem, disease state, technology, methodology, or training need related to CV disease and DCVD’s mission. Each provides examples of directions that may drive progress toward the goal, though stopping short of specifying research initiatives or project proposals. For most research goals, progress will require basic, translational, and clinical investigation. Wherever possible, the examples provided in this document span the entire range of research.
Within each of these three broad categories, the DCVD fully promotes research focused on underserved or underrepresented population subgroups such as pediatric (including fetal through pre-adulthood), women, minorities (ethnic and racial), low socioeconomic status, rural, and diverse groups. In addition, the DCVD supports rare diseases research, and staff work closely with members of the scientific, clinical, and patient communities toward this end.
The DCVD intends to develop initiatives directed toward achieving the goals identified within its Strategic Plan. These initiatives will focus on complementing, rather than replicating, ongoing investigator-initiated research. Toward this end, our next task (ongoing) is to survey research funding, activity, and publications to identify and prioritize research opportunities responsive to the DCVD Strategic Plan goals that would most benefit from stimulation/support from the NHLBI.
Many of the goals articulated in this DCVD Strategic Plan are shared by other Divisions within the NHLBI and by Divisions of other Institutes. In pursuing these goals, DCVD particularly intends to partner with the NHLBI Division of Prevention and Population Sciences, Division of Lung Diseases, Division of Blood Diseases and Resources, and Division of the Application of Research Discoveries.
The NHLBI boosts support for areas of research through funding opportunity announcements (FOAs) such as Requests for Applications (RFAs; grants with set-aside funding), Requests for Proposals (RFPs; contracts with set-aside funding), and Program Announcements (PAs; grant programs usually with no specific set-asides). In addition, the DCVD/NHLBI may convene targeted stand-alone workshops that generate research recommendations from the extramural research community (see http://www.nhlbi.nih.gov/research/reports/index.htm for Executive Summaries and their research recommendations for recently held workshops). Finally, the Small Business Innovation Research (SBIR) and the Small Technology Transfer Research (STTR) programs provide excellent opportunities for bringing technology and methodology to market readiness. These programs are funded by grants and contracts and have legislatively mandated set-asides.
In the coming years, we will measure success by gauging the steps taken and progress achieved toward attaining these goals. In general, boosting support for research areas will lead to success by one or more of the following measures:
As with the overall NHLBI Strategic Plan, the DCVD Strategic Plan is intended to be a “living” document that will be updated periodically as progress is achieved, new challenges emerge, and we gain feedback from the extramural research community.
This Strategic Plan is dedicated to the memory of Ms. Elizabeth Pitt, who devoted herself to the NHLBI and its mission to advance cardiovascular knowledge and health for 19 years.