The Division of Blood Diseases and Resources (DBDR) is part of the National Heart, Lung, and Blood Institute (NHLBI), one of 27 Institutes and Centers at the National Institutes of Health (NIH). DBDR supports research on the causes, prevention, and treatment of nonmalignant blood diseases, including anemias, sickle cell disease, and thalassemia; premalignant processes such as myelodysplasia and myeloproliferative disorders; hemophilia and other abnormalities of hemostasis, thrombosis and the microvasculature; hematopoiesis and immune dysfunction. Funding encompasses a broad spectrum of research ranging from basic biology to medical management of blood diseases.
The Division has a major responsibility for research to assure the adequacy and safety of the Nation's blood supply. The Division also has a leading role in applying scientific advances in transfusion medicine, stem cell biology and systems biology to the development of new gene and cell-based therapies to repair and regenerate human tissues and organs. DBDR has three branches: the Blood Epidemiology and Clinical Therapeutics Branch, the Molecular Cellular and Systems Blood Science Branch, and the Translational Blood Science and Resources Branch.
Office of the Director
Oversight over all Divisional activities. More specifically, the Office of the Director 1) plans and coordinates the activities of all Branches responsible for supporting and managing discovery, translational and clinical research programs across the blood sciences; (2) continuously assesses the Institute's national and international health programs related to all blood science disciplines and resources; (3) fosters and coordinates interdivisional, trans-NHLBI, trans-NIH and interagency collaborative and cooperative research arrangements; (4) develops and maintains the necessary scientific management capability in the Division to foster and guide effective programs in blood sciences and resources management; (5) plans, coordinates, and directs special activities that transcend program lines including minority, small business, and education research programs; (6) provides program analysis and administrative support services for the Division; and (7) oversees Divisional programs to support the workforce in nonmalignant hematology.
W. Keith Hoots, M.D., Director
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Donna M. DiMichele M.D., Deputy Director
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Blood Epidemiology and Clinical Therapeutics Branch
Oversight, support and stimulation of epidemiologic, clinical and implementation research throughout the spectrum of blood science. Branch responsibilities include: 1) oversight, support and stimulation of epidemiologic, health services and observational clinical research; 2) oversight, support and stimulation of therapeutic and interventional clinical trials [T3 Research]; 3) acquisition and maintenance of expertise in clinical study and trial design and administration on behalf of the Division; 4) oversight, support and stimulation of implementation science and research [T4 Research]; 5) training of the blood science workforce; and 6) serving as scientific liaison for epidemiologic, clinical and implementation research across the Division, NHLBI, NIH and partner federal agencies.
Simone Glynn, M.D., M.Sc., M.P.H, Branch Chief
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Molecular Cellular and Systems Blood Science Branch
Oversight, support and stimulation of fundamental basic research and early stage laboratory translation of the biology of blood, the blood forming elements and the interface between each of the latter with other cellular and organ systems. Branch responsibilities include: 1) oversight, support and stimulation of discovery science focused on the explication of the physiology and pathophysiology of blood, bone marrow and the interaction of blood cells and components with the vasculature; 2) oversight, support and stimulation of systems biological approaches to discovering the critical role of blood/bone marrow/vascular endothelium in animal and human organs and organisms; 3) oversight, support and stimulation of the application of fundamental genetic, proteomic and metabolomic tools toward the complete understanding of hematologic physiology and pathophysiology; 4) administration of and/or liaison to NHLBI, NIH resources related to basic research in non-neoplastic hematology, as well as cell and gene therapies for blood diseases; 5) training of the blood science workforce; and, 6) fostering scientific communication across the Division, NHLBI, NIH and partner federal agencies to engender bench to bedside translation.
Yu-Chung Yang, Ph.D., Branch Chief
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Translational Blood Science and Resources Branch
Oversight, support and stimulation of translational research throughout the spectrum of blood science, as well as the resources required to support heart, lung, blood, and sleep research. Branch responsibilities include: 1) oversight, support and stimulation of post-discovery science, preclinical research, and early phase clinical studies and trials [T1,T2 Research] including the development of therapeutics or devices; 2) oversight, support and stimulation of SBIR/STTR initiatives in blood sciences; 3) administration of and/or liaison to NHLBI resources related to translational research which may include cell and gene therapy, preclinical animal models, pharmacology/toxicology studies, small molecule/biologics studies, and drug repurposing studies; 4) training of the blood science workforce to develop and maintain investigators with experience in diverse areas such as bench to bedside research, clinical trials (early and late phase), veterinary medicine with a blood science focus, and epidemiology including rare disorders and orphan indications; and 5) serving as scientific liaison for translational research across the Division, NHLBI, NIH and partner federal agencies.
Traci Heath Mondoro, Ph.D., Branch Chief
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Division of Blood Diseases and Resources
The National Heart, Lung and Blood Institute
Two Rockledge Center, Suite 9030
6701 Rockledge Dr. MSC 7950
Bethesda, Maryland 20892-7950