NHLBI Research and Outreach Programs
Research Studies
- Arsenic and Child Respiratory Health in Bangladesh
- Oxidative Response Networks in Chagasic Cardiomyopathy
- Retrovirus Epidemiology Donor Study-II (REDS-II)
- Sodium Sensitivity and Risk of Hypertension
- The Genetic Epidemiology of Asthma in Costa Rica
- The Genetic Epidemiology of COPD in Costa Rica
Clinical Trials
- Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL)
- FREEDOM Trial: Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease
- International HIV-associated Opportunistic Pneumonias (IHOP) Study
- Surgical Treatment for Ischemic Heart Failure (STICH)
- Trial to Assess Chelation Therapy (TACT)
- Thalassemia (Cooley’s Anemia) Clinical Research Network
Research Studies
Arsenic and Child Respiratory Health in Bangladesh
Description: Examine the possible detrimental effects of arsenic in drinking water on lung growth and function in 600 children, ages 6 to 16, living in, Bangladesh.
Lead Institution: University of California, Berkeley, Berkeley, California, USA
Partner Organization: International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh
Site: Bangladesh
Oxidative Response Networks in Chagasic Cardiomyopathy
Description: A study of the pathogenic mechanisms that lead to heart failure in people with Chagas disease. The cross-sectional study is being conducted in 770 persons who have different clinical stages of Chagas disease living in an endemic area of northern Argentina.
Lead Institution: University of Texas Medical Branch, Galveston, Texas, USA
Partner Organizations: Catholic University of Santiago del Estero, Santiago del Estero, Argentina; National University of Cordoba, Cordoba, Argentina
Site: Argentina
Retrovirus Epidemiology Donor Study-II (REDS-II)
Description: The international component of the REDS-II is conducting epidemiological, laboratory, and survey research on blood donors in China and Brazil, countries that have been seriously impacted by the AIDS epidemic. Blood centers in those countries are addressing critical scientific issues related to transmission of HIV and other established and emerging transfusion-transmitted agents.
Lead Institution: Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Partner Organizations: Institute of Blood Transfusion, Chengu, Sichuan, China; Blood Systems Research Institute, San Francisco, California, USA; Fundacao Faculdade de Medicina, San Paulo, Brazil
Sites: China; Brazil
Sodium Sensitivity and Risk of Hypertension
Description: Examine how high blood pressure (hypertension) develops in relation to sodium and potassium, and the relationship between genes and the risk of hypertension.
Lead Institution: Tulane University, New Orleans, Louisiana, USA
Partner Organization: Cardiovascular Institute and Fuwai Hospital, Beijing, China
Site: China
The Genetic Epidemiology of Asthma in Costa Rica
Description: Identify asthma-susceptibility genes in a genetically isolated Hispanic population with high prevalence of asthma in the Central Valley of Costa Rica.
Lead Institution: Brigham and Women’s Hospital, Boston, Massachusetts, USA
Partner Organization: Hospital Nacional de Niños, San José, Costa Rica
Site: Costa Rica
The Genetic Epidemiology of COPD in Costa Rica
Description: Identify genetic determinants of COPD-related phenotypes in 30 large Hispanic families with a high prevalence of COPD living in the Central Valley of Costa Rica.
Lead Institution: Brigham and Women’s Hospital, Boston, Massachusetts, USA
Partner Organization: Hospital Nacional de Niños, San José, Costa Rica
Site: Costa Rica
Clinical Studies
Cardiovascular Outcomes in Renal Atherosclerotic Lesions (CORAL)
Purpose: Determine whether revascularization of a stenotic renal artery plus medical therapy is associated with improved clinical outcomes compared with medical therapy alone. Twenty-three percent of the participants will be from minority populations.
Foreign Sites: Argentina, Australia, Brazil, Canada, France, Germany, Lithuania, Netherlands, New Zealand, South Africa, United Kingdom
FREEDOM Trial: Future Revascularization Evaluation in Patients With Diabetes Mellitus: Optimal Management of Multivessel Disease
Purpose: Address the critically important problem of how to best revascularize diabetic individuals with multivessel coronary artery disease. The main objective is to evaluate whether percutaneous coronary intervention with drug-eluting stenting is more or less effective than the existing standard of care, coronary artery bypass graft.
Foreign Sites: Argentina, Australia, Belgium, Brazil, Canada, Chile, Colombia, Czech Republic, France, Germany, India, Ireland, Israel, Italy, Mexico, New Zealand, Poland, Spain, Switzerland, United Kingdom
International HIV-associated Opportunistic Pneumonias (IHOP) Study
Purpose: Create an international, multi-center, longitudinal cohort that reflects the HIV/AIDS epidemic in Africa, Europe, and North America to study pneumocystis carinii pneumonia and opportunistic pneumonias.
Sites: Uganda, United Kingdom
Surgical Treatment for Ischemic Heart Failure (STICH)
Purpose: Determine whether coronary artery bypass graft (CABG) plus intensive medical therapy improves long-term survival of patients with heart failure and left ventricular (LV) dysfunction who have coronary artery disease amenable to surgical revascularization, compared to medical therapy alone; and to determine whether CABG plus surgical ventricular restoration to a more normal LV size improves survival free of subsequent hospitalizations of patients with anterior LV dysfunction, compared to CABG alone.
Foreign Sites: Argentina, Australia, Belarus, Belgium, Brazil, Canada, Chile, Czech Republic, Germany, Hungary, India, Italy, Lithuania, Macedonia, Malaysia, New Zealand, Norway, Poland, Russia, Singapore, Sweden, Switzerland, Thailand, Turkey, United Kingdom, Uruguay
Trial to Assess Chelation Therapy (TACT)
Purpose: Determine the safety and effectiveness of ethylene diamine tetra-acetic (EDTA) chelation therapy in individuals with coronary artery disease in people age 50 and older. Co-funded with the National Center for Complementary and Alternative Medicine.
Foreign Sites: Argentina, Canada
Thalassemia (Cooley’s Anemia) Clinical Research Network
Purpose: Accelerate research in the management of thalassemia, standardize existing treatments, and evaluate new ones in a network of clinical centers.
Foreign Sites: Australia, Canada, Hong Kong, Italy, Lebanon, Switzerland, Thailand, Turkey, United Kingdom
Last Updated: September 30, 2009
