Types of Research Activity
Project Grants (R01): To
support discrete and specific projects by one or several investigators in areas
of the investigator's particular interests and competencies.
Research Projects (Cooperative
Agreements) (U01): To support discrete, circumscribed projects in areas
of an investigator's specific interest and competency involving substantial
programmatic participation by the NHLBI during performance of the
Research Program (Cooperative Agreement)
(U19): To support a research program of multiple projects, requiring a
broadly-based, multidisciplinary and often long-term approach, directed toward
a specific major objective, common theme, or program goal relevant to the
Institute's mission. The award involves substantial programmatic involvement
by NHLBI staff to assist investigators during performance of the research
Research Program Projects (P01): To
support broadly based, multidisciplinary, often long-term research projects
that have specific major objectives or basic themes directed toward a
well-defined research program goal. Usually, a relatively large, organized
group of researchers conducts individual subprojects, the results of which help
achieve objectives of the program project.
Small Research Grants (R03): To
provide limited support for extended analyses of research data generated by
clinical trials, population research, and demonstration and education studies.
Academic Research Enhancement Awards
(AREA) (R15): To support small-scale research projects in the
biomedical and behavioral sciences conducted by faculty and students at
educational institutions that have not been major recipients of NIH research
grant funds. Awards are for up to $75,000 for direct costs (plus applicable
indirect costs) for periods not to exceed 36 months.
Exploratory/Developmental Grants (R21): To encourage the development of new research activities in heart, lung,
and blood diseases and sleep disorders program areas.
Exploratory/Developmental Grant (R33): To
pro-vide phase II support for innovative exploratory and developmental research
activities initiated under the R21 mechanism.
Clinical Trial Planning Grant (R34): To support
pilot studies to obtain data that are critical to the successful design of a
full-scale clinical trial.
Method To Extend Research in Time (MERIT)
Award (R37): To provide long-term research grant support to
investigators whose research competency and productivity are distinctly
superior and thus are likely to continue to perform in an outstanding manner. Investigators may not apply for a MERIT award; instead, they are selected by
the NHLBI on the basis of their current grant applications and their present
and past grant support. As of July 2011, no new nominations for MERIT awards
are being made.
Grant Cooperative Agreement (U34):
To support pilot studies to obtain data that are critical to the successful
design of a full-scale clinical trial. The award involves substantial
programmatic involvement by NHLBI staff to assist investigators during
performance of the research activities.
NIH Director's Pioneer Award (DP1): To
support individual scientists of exceptional creativity who propose bold and
highly innovative approaches that have the potential to produce a major impact
on broad, important problems in biomedical and behavioral research.
NIH Director's New Innovator Award
(DP2): To support exceptionally creative new investigators who propose
highly innovative approaches that have the potential to produce an unusually
Cooperative Agreements Phase I (UH2): To support the development of new
research activities in program areas that are relevant to the Institute's
mission. Support is generally restricted in level of support and in time. The
award requires substantial programmatic involvement by NHLBI staff to assist
investigators during the performance of research activities.
Multi-Component Research Project Cooperative Agreements (UM1): To support large-scale cooperative agreements
that involve complex clinical trials with multiple components (e.g., clinical
networks that are relevant to the Institute's mission). The components
represent a variety of supporting functions and are not independent of the
research projects. The award requires substantial programmatic involvement by
NHLBI staff to assist investigators during the performance of research
Business Technology Transfer (STTR) Grants—Phase I (R41): To support
cooperative R&D projects between small business concerns and research
institutions, limited in time and amount, to establish the technical merit and
feasibility of ideas that have potential for commercialization.
Business Technology Transfer (STTR) Grants—Phase II (R42): To support
in-depth development of cooperative R&D projects between small business
concerns and research institutions, limited in time and amount, whose
feasibility has been established in phase I and that have potential for
Business Innovation Research (SBIR) Grants, Phase I (R43): To support
projects, limited in time and amount, to establish the technical merit and
feasibility of research and development ideas that may ultimately lead to
commercial products or services.
Business Innovation Research (SBIR) Grants, Phase II (R44): To support
research project ideas that have been shown to be feasible in phase I and that
are likely to result in commercially marketable products or services.
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Grants (P20): To support planning for new programs, expansion or
modification of existing resources, and feasibility studies to explore various
approaches to the development of interdisciplinary programs that offer
potential solutions to problems of special significance to the mission of the
Grants (P30): To establish research centers to augment research
capabilities and resources in biomedical and behavioral research related to
heart, lung, blood, and sleep diseases and disorders.
Research Grants (P50): To accelerate the translation of promising new
therapeutic interventions that are derived from fundamental research
discoveries to treat and prevent cardiovascular, lung, and blood diseases
through planning and executing well-designed clinical trials that demonstrate
safety and efficacy.
Centers of Clinically Oriented Research (SCCOR) Grants (P50): To foster
multidisciplinary research on clinically relevant questions enabling basic
science findings to be applied more rapidly to clinical problems. Research
focuses on clinical and basic scientific issues related to diseases and
disorders that are relevant to the mission of the NHLBI. The SCCOR program
places more emphasis on clinical research than the SCOR program and requires at
least 50 percent of the funded projects to be clinical.
National Swine Research and Resource
Center (U42): To support a National Swine Research and Resource Center
that will serve as a resource for depositing, maintaining, preserving, and
distributing swine models for studies of human diseases, as well as
cryopreservation, storage, and reconstitution of embryos and germplasm.
Centers Grants (U54): To support large, interrelated biomedical
research that is focused on a disorder within the Institute's mandate and to
enhance the translation of basic research discoveries that could lead to
improved prevention, diagnosis, and treatment of thrombotic and hemostatic
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Research Career Programs
Mentored Career Development Award To
Promote Faculty Diversity in Biomedical Research* (K01): To support
underrepresented minority faculty members with varying levels of research
experience to prepare them for research careers as independent investigators.
Scientist Development Award in Research Ethics (K01): To provide
support for training in research ethics for health professionals working at
academic and other health-related institutions in biomedical, behavioral, or
public health research, particularly research involving human participants.
Career Award for Faculty at Minority-Serving Institutions** (K01): To
support faculty members at minority institutions who have the interest and
potential to conduct state-of-the-art research in cardiovascular, pulmonary, or
hematologic disease or in sleep disorders.
Scientist Award (K02): To enhance the research capability of promising
individuals in the formative stages of their careers of independent research in
sciences related to heart, lung, and blood diseases; blood resources; and sleep
Award (K07): To support an individual interested in introducing or
improving curricula in a particular scientific field as a means of enhancing
the educational or research capacity at the grantee institution and the
individual's own career. This program includes Academic Awards in
Tuberculosis, Sleep, Nutrition, Cultural Competence and Health Disparities, and
Pediatric Transfusion Medicine. Currently, the Career Development program is
supporting Innovators in Hemoglobinopathies Care.
Clinical Investigator Development Award (K08): To provide an opportunity for clinically trained
physicians to develop research skills and gain experience in advanced research
methods and experimental approaches in basic and applied sciences relevant to
cardiovascular, pulmonary, and hematological diseases and sleep disorders.
Career Development Program (K12): To promote comprehensive clinical
research training for physicians to prepare them for academic roles in
mentoring and leadership in clinical research. The program supports research
training in vascular medicine, clinical hematology and transfusion medicine,
genetics and genomics of lung diseases, and emergency medicine.
Career Enhancement Award for Stem Cell
Research (K18): To enable established investigators to acquire new research
capabilities in the use of human or animal embryonic, adult, or cord blood stem
cells. All candidates must have a sponsor, either within their own or at
another institution, who is a well-qualified stem cell expert to serve as a
Transition Award (K22): To support the postdoctoral research training
of an outstanding individual in an NHLBI intramural laboratory for up to
3 years and subsequently, to support the individual's successful
transition from postdoctoral research to an extramural environment as an
Mentored Patient-Oriented Research Career
Development Award (K23): To
support the career development of investigators who have made a commitment to
focus their research endeavors on patient-oriented research.
Investigator Award in Patient-Oriented Research (K24): To provide
support for clinicians to allow them “protected time” to devote to
patient-oriented research and to act as mentors for beginning clinical
Quantitative Research Career Development Award (K25): To support
investigators with quantitative science or engineering backgrounds who have
made a commitment to focus their research on basic or clinical biomedicine,
bioengineering, bio-imaging, or behavioral sciences.
Independence (K99/R00): To provide up to 5 years support in two phases
to highly promising postdoctoral scientists to pursue research relevant to the
Institute. The K99 phase (Career Transition Award) consists of 1 or 2 years of
mentored support, followed by the R00 phase (Research Transition Award) of up
to 3 years of independent support, which is contingent on securing an
independent research position. Award recipients will be expected to compete
successfully for independent research grant support from the NIH or other
Institutions during the independence phase to ensure continued support and a
smooth transition to independence.
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Other Research Grants
Clinical Research (R10) (U10): To support studies and evaluations of
relevant clinical problems. These grants usually involve collaborative efforts
among several institutions and principal investigators and are conducted under
a formal protocol.
Conference Grants (R13): To
support national and international scientific meetings, conferences, or
workshops at which research is discussed.
Research Demonstration and Education
Projects (R18): To support the development, testing, and evaluation of
health-related activities and to foster application of existing knowledge to
the control of heart, lung, and blood diseases and sleep disorders.
Research Projects (R24): To support
research projects that will enhance the capability of resources to serve
biomedical research in areas related to cardiovascular, lung, and blood
health and diseases; blood resources; and sleep disorders.
Education Projects (R25): To increase the number of students from
underrepresented groups in biomedical and behavioral research who complete the
Ph.D. degree programs in these fields. The program offers an opportunity to
develop new or expand existing effective academic developmental programs,
including student research internships, in order to prepare students from
underrepresented groups for competitive research careers and leadership
positions in the biomedical or behavioral sciences.
Biomedical Research Support Grants (S06): To strengthen the
biomedical research and research training capability of minority institutions
and to assist in increasing the involvement of minority faculty and students in
Award (SC1): To support individual investigator-initiated research
projects aimed at developing researchers at minority-serving institutions to a
stage where they can transition successfully to other extramural support.
Project Award (SC2): To support underrepresented minorities who are at
the beginning stages of a research career and interested in testing a new idea
or generating preliminary data, or who are more experienced investigators and
interested in switching to a different field of research.
Education Training Grant (T15): To assist professional schools and
other public and nonprofit institutions to establish, expand, or improve
programs of continuing professional education, especially for programs dealing
with new scientific developments.
Research Projects (U24): To support research projects contributing to
improvement of the capability of resources to serve biomedical research.
Historical Black College and University
Scientist Award (UH1): To augment human resources at historically black
colleges and universities (HBCU) by recruiting an established research
scientist into their biomedical or behavioral sciences department; to enhance
the career of the recruited research scientist; and to strengthen other HBCU
resources for the conduct of biomedical or behavioral research in areas related
to cardiovascular, lung, and blood health and disease; transfusion medicine;
and sleep disorders.
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Individual National Research
Service Awards (NRSA)
Individual Predoctoral M.D. /Ph.D. NRSA
(F30): To provide predoctoral individuals with supervised research
training in areas related to heart, lung, and blood diseases; blood resources;
and sleep disorders leading toward a combined M.D. /Ph.D. degree. Training
under this award is designed to provide a foundation for a career as a
physician-scientist in the areas of interest to the NHLBI.
Predoctoral Individual NRSA (F31): To
provide predoctoral individuals with supervised research training in areas
related to heart, lung, and blood diseases; blood resources; and sleep
disorders leading toward the research degree (e.g. , Ph.D. ).
Postdoctoral Individual NRSA (F32): To
provide postdoctoral research training to individuals to broaden their
scientific background and extend their potential for research in areas related
to heart, lung, and blood diseases and blood resources and sleep disorders.
NRSA for Senior Fellows (F33): To
provide experienced scientists with an opportunity to make major changes in the
direction of their research careers, to broaden their scientific background, to
acquire new research capabilities, to enlarge their command of an allied
research field, or to take time from regular professional responsibilities for
the purpose of broadening their research capabilities.
Institutional National Research Service Awards (NRSA)
Institutional NRSA (T32): To
enable institutions to make awards to individuals selected by them for predoctoral
and postdoctoral research training in areas related to heart, lung, and blood
diseases; blood resources; and sleep disorders.
Minority Institutional Research Training
Program (T32M): To support full-time research training for
investigative careers at minority schools in areas of cardiovascular,
pulmonary, and hematologic diseases and sleep disorders. Graduate students,
postdoctoral students, or health professions students may be supported under
MARC Undergraduate NRSA Institutional
Grants (T34): To support institutional training grants for
underrepresented minority undergraduates to obtain research training and
improve their preparation for graduate training in the biomedical and
NRSA Short-Term Research Training (T35
and T35M): To provide individuals with research training during
off-quarters or summer periods to encourage research careers or to encourage
research in areas of national need. This program includes the Short-Term
Training for Minority Students Program and short-term training for students in
health professional schools.
Visiting Professors for Minority Institutions (T36): To increase the number of well-trained minority
scientists in biomedical disciplines and to strengthen the research and
teaching capabilities of minority institutions.
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Research and Development Contracts
(N01): To develop or apply new knowledge or test, screen, or evaluate a
product, material, device, or component for use by the scientific community.
Small Business Innovation Research
(N43): To support projects, limited in time and amount, to establish
the technical merit and feasibility of R&D ideas that may ultimately lead
to a commercial product(s) or service(s).
NIH Inter-Agency Agreements (Y01): To
provide a source of funds to another Federal Agency to acquire specific
products, services, or studies.
NIH Intra-Agency Agreements (Y02): To
provide a source of funds to another NIH component to acquire specific
products, services, or studies.
Minority Research Supplements Programs: To provide supplemental funds to active NHLBI grants to support the
research of minority high school, undergraduate, and graduate students;
postdoctoral trainees; and investigators.
* Formerly known as Mentored Research Scientist Development
Award for Minority Faculty.
** Formerly known as Minority Institution Faculty Mentored
Research Scientist Development Award.
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