Types of Research Activity
Research Projects
Research Project Grants (R01): To support
discrete and specific projects to be performed by one or several investigators
in areas of the investigator's particular interests and competencies.
Research Projects (Cooperative Agreements) (U01): To support discrete, circumscribed projects in areas of an
investigator's specific interest and competency involving substantial
programmatic participation by the NHLBI during performance of the
activity.
Research Program (Cooperative Agreement) (U19): To support a research program of multiple projects, requiring a
broadly-based, multidisciplinary and often long-term approach, directed toward
a specific major objective, common theme, or program goal relevant to the
Institute's mission. The award involves substantial programmatic
involvement by NHLBI staff to assist investigators during performance of the
research activities.
Research Program Projects (P01): To support
broadly based, multidisciplinary, often long-term research projects that have
specific major objectives or basic themes directed toward a well-defined
research program goal. Usually, a relatively large, organized group of
researchers conducts individual subprojects, the results of which help achieve
objectives of the program project.
Small Research Grants (R03): To provide limited
support for extended analyses of research data generated by clinical trials,
population research, and demonstration and education studies.
Academic Research Enhancement Awards (AREA) (R15): To support small-scale research projects conducted by faculty in
primarily baccalaureate degree-granting domestic institutions. Awards are
for up to $75,000 for direct costs (plus applicable indirect costs) for periods
not to exceed 36 months.
Exploratory/Developmental Grants (R21): To
encourage the development of new research activities in heart, lung, and blood
diseases and sleep disorders program areas.
Exploratory/Developmental Grant (R33): To
provide phase II support for innovative exploratory and developmental research
activities initiated under the R21 mechanism.
Clinical Trial Planning Grant (R34): To support the initial
development of a clinical trial, including establishment of the research team;
development of tools for data management and oversight of the research; and
development of a trial design and other essential elements of the study, such
as the protocol, recruitment strategies, and procedure manuals.
Method To Extend Research in Time (MERIT) Award (R37): To provide long-term research grant support to investigators whose
research competency and productivity are distinctly superior and thus are
likely to continue to perform in an outstanding manner. Investigators may
not apply for a MERIT award; instead, they are selected by the NHLBI on the
basis of their current grant applications and their present and past grant
support.
Clinical Planning Grant Cooperative Agreement (U34): To
support the initial development of a clinical trial, including establishment of
the research team; development of tools for data management and oversight of
the research; and development of a trial design and other essential elements of
the study, such as the protocol, recruitment strategies, and procedure
manuals. The award involves substantial programmatic involvement by NHLBI
staff to assist investigators during performance of the research
activities.
NIH Director's Pioneer Award (DP1): To support
individual scientists of exceptional creativity who propose pioneering
approaches to major contemporary challenges in biomedical research.
NIH Director's New Innovator Award (DP2): To
support exceptionally creative new investigators who propose highly innovative
approaches that have the potential to produce an unusually high impact.
The New Innovator Award will emphasize the importance and potential impact of
the scientific problem, the novelty and innovativeness of the approach, and the
applicant's potential for creative and innovative research.
Linked Research Project Grant (RL1): To support a discrete,
specified, circumscribed project that is administratively linked to another
project or projects.
Exploratory/Developmental Cooperative Agreements Phase I
(UH2): To support the development of new research activities in
program areas that are relevant to the Institute's mission. Support is
generally restricted in level of support and in time. The award requires
substantial programmatic involvement by NHLBI staff to assist investigators
during the performance of research activities.
Multi-Component Research Project Cooperative Agreements
(UM1): To support large-scale cooperative agreements that involve
complex clinical trials with multiple components (e.g., clinical networks that
are relevant to the Institute's mission). The components represent a
variety of supporting functions and are not independent of the research
projects. The award requires substantial programmatic involvement by
NHLBI staff to assist investigators during the performance of research
activities.
Small Business Technology Transfer (STTR) Grants—Phase I
(R41): To support cooperative R&D projects between small
business concerns and research institutions, limited in time and amount, to
establish the technical merit and feasibility of ideas that have potential for
commercialization. Awards are made to small business concerns only.
Small Business Technology Transfer (STTR) Grants—Phase II
(R42): To support in-depth development of cooperative R&D
projects between small business concerns and research institutions, limited in
time and amount, whose feasibility has been established in phase I and that
have potential for commercialization. Awards are made to small business
concerns only.
Small Business Innovation Research (SBIR) Grants, Phase I
(R43): To support projects, limited in time and amount, to
establish the technical merit and feasibility of research and development ideas
that may ultimately lead to commercial products or services.
Small Business Innovation Research (SBIR) Grants, Phase II
(R44): To support research project ideas that have been shown to
be feasible in phase I and that are likely to result in commercially marketable
products or services.
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Research Centers
Exploratory Grants (P20): To support planning for
new programs, expansion or modification of existing resources, and feasibility
studies to explore various approaches to the development of interdisciplinary
programs that offer potential solutions to problems of special significance to
the mission of the NHLBI.
Center Core Grants (P30): To support shared
resources and facilities for basic, clinical, behavioral,
and translational research in the prevention, detection, and treatment of
HIV infection and AIDS.
Specialized Centers of Clinically Oriented Research (SCCOR)
Grants (P50): To foster multidisciplinary research on clinically
relevant questions enabling basic science findings to be applied more rapidly
to clinical problems. Research focuses on clinical and basic scientific
issues related to diseases and disorders that are relevant to the mission of
the NHLBI. The SCCOR program places more emphasis on clinical research
than the SCOR program and requires at least 50 percent of the funded projects
to be clinical.
National Swine Research and Resource Center (U42): To support a National Swine Research and Resource Center that will
serve as a resource for depositing, maintaining, preserving, and distributing
swine models for studies of human diseases, as well as cryopreservation,
storage, and reconstitution of embryos and germplasm.
Comprehensive Specialized Research Center Grants (U54): To support a large, interrelated biomedical research program focused
on a disorder within the Institute's mandate; to initiate and expand community
education, screening, and counseling programs; and to educate medical and
allied health professionals concerning problems of diagnosis and treatment of
specific diseases such as sickle cell anemia.
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Research Career Programs
Mentored Research Scientist Development Award for Minority
Faculty (K01): To support underrepresented minority faculty
members with varying levels of research experience to prepare them for research
careers as independent investigators.
Mentored Scientist Development Award in Research Ethics
(K01): To provide support for training in research ethics for
health professionals working at academic and other health-related institutions
in biomedical, behavioral, or public health research, particularly research
involving human participants.
Minority Institution Faculty Mentored Research Scientist
Development Award (K01): To support faculty members at minority
institutions who have the interest and potential to conduct state-of-the-art
research in cardiovascular, pulmonary, or hematologic disease or in sleep
disorders.
Independent Scientist Award (K02): To enhance the
research capability of promising individuals in the formative stages of their
careers of independent research in the sciences related to heart, lung, and
blood diseases; blood resources; and sleep disorders.
Academic Award (K07): To support an individual
with an academic appointment to introduce or improve a disease curriculum that
will enhance the academic or research environment of the applicant institution
as well as further the individual's own career. This award series
included the Tuberculosis Academic Award, the Sleep Academic Award, and the
Nutrition Academic Award. Currently, the Pediatric Transfusion Medicine
Academic Award and the Innovators in Hemoglobinopathies Care Career Development
Award programs are being supported.
Clinical Investigator Development Award (K08): To
provide an opportunity for clinically trained physicians to develop research
skills and gain experience in advanced research methods and experimental
approaches in basic and applied sciences relevant to cardiovascular, pulmonary,
and hematological diseases.
Research Career Development Program in Vascular Medicine
(K12): To promote comprehensive clinical research training for
physicians wanting to specialize in vascular medicine. The goal is to
prepare clinicians for academic roles in mentoring and leadership in clinical
research in vascular medicine.
Research Career Development Program in Clinical Hematology
(K12): To develop and evaluate multidisciplinary career
development programs in clinical hematology research that will equip new
academic researchers with the knowledge and skills to address complex problems
in blood diseases, transfusion medicine, and cellular therapies.
Research Career Development Program in the Genetics and Genomics
of Lung Diseases (K12): To develop multidisciplinary career
development programs in genetics and genomics of lung diseases that will equip
new investigators with the knowledge and skills to elucidate the etiology and
pathogenesis of such diseases.
Clinical Research Career Development Programs in Emergency Medicine
(K12): To promote multidisciplinary clinical research training
programs in emergency medicine that prepare clinician-scientists for
independent research careers and academic leadership roles in emergency
medicine. Programs will provide comprehensive research training to
evaluate innovative approaches in the diagnosis and clinical management of
patients with acute, life-threatening manifestations of cardiovascular,
pulmonary, and hematologic diseases and severe trauma in emergency department
settings.
Career Enhancement Award for Stem Cell Research (K18): To enable established investigators to acquire new research
capabilities in the use of human or animal embryonic, adult, or cord blood stem
cells. All candidates must have a sponsor, either within their own or at
another institution, who is a well-qualified stem cell expert to serve as a
mentor.
NHLBI Career Transition Award (K22): To support
the postdoctoral research training of an outstanding individual in an NHLBI
intramural laboratory for up to 3 years and subsequently, to support the
individual's successful transition from postdoctoral research to an extramural
environment as an independent researcher.
Mentored Patient-Oriented Research Career Development Award
(K23): To provide support for career development to
investigators who have made a commitment to focus their research endeavors on
patient-oriented research.
Midcareer Investigator Award in Patient-Oriented Research
(K24): To provide support for clinicians to allow them
“protected time” to devote to patient-oriented research and to act as
mentors for beginning clinical investigators.
Mentored Quantitative Research Career Development Award
(K25): To provide support to investigators with quantitative
science or engineering backgrounds who have made a commitment to focus their
research on basic or clinical biomedicine, bioengineering, bioimaging, or
behavioral sciences.
Pathway to Independence (K99/R00): To provide up
to 5 years support in two phases to highly promising postdoctoral scientists to
pursue research relevant to the Institute. The K99 phase (Career
Transition Award) consists of 1 or 2 years of mentored support, followed by the
R00 phase (Research Transition Award) of up to 3 years of independent support,
which is contingent on securing an independent research position. Award
recipients will be expected to compete successfully for independent research
grant support from the NIH or other Institutions during the independence phase
to ensure continued support and a smooth transition to independence.
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Other Research Grants
Cooperative Clinical Research (R10) (U10): To
support studies and evaluations of relevant clinical problems. These
grants usually involve collaborative efforts among several institutions and
principal investigators and are conducted under a formal protocol.
Conference Grants (R13): To support national and
international scientific meetings, conferences, or workshops at which research
is discussed.
Research Demonstration and Education Projects (R18): To provide support designed to develop, test, and evaluate
health-related activities and to foster application of existing knowledge to
the control of heart, lung, and blood diseases and sleep disorders.
Resource-Related Research Projects
(R24): To support research
projects that will enhance the capability of resources to serve biomedical
research in areas related to cardiovascular, lung, and blood health
and diseases; blood resources; and sleep disorders.
Education Projects (R25): To provide support for the
development and implementation of a program as it relates to a category in one
or more of the areas of education, information, training, technical assistance,
coordination, or evaluation.
Minority Biomedical Research
Support Grants (S06): To strengthen the biomedical research and
research training capability of minority institutions and to assist in
increasing the involvement of minority faculty and students in biomedical
research.
Research Enhancement Award (SC1): To support individual investigator-initiated research projects aimed
at developing researchers at minority-serving institutions to a stage where
they can transition successfully to other extramural support.
Pilot Project Award (SC2): To support underrepresented minorities who are at the beginning stages
of a research career and interested in testing a new idea or generating
preliminary data, or who are more experienced investigators and interested in
switching to a different field of research.
Continuing Education Training Grant
(T15): To assist professional schools and other public and
nonprofit institutions to establish, expand, or improve programs of continuing
professional education, especially for programs dealing with new scientific
developments.
Resource-Related Research Projects
(U24): To support research projects contributing to improvement
of the capability of resources to serve biomedical research.
Historical Black College and University Scientist Award
(UH1): To strengthen and augment the human resources at
historically black colleges and universities (HBCU) by recruiting an
established research scientist into their biomedical or behavioral sciences
department; to enhance the career of the recruited research scientist; and to
strengthen other HBCU resources for the conduct of biomedical or behavioral
research in areas related to cardiovascular, lung, and blood health and
disease; transfusion medicine; and sleep disorders.
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Individual National Research
Service Awards (NRSA)
Individual Predoctoral M.D./Ph.D. NRSA (F30): To provide predoctoral individuals
with supervised research training in areas related to heart, lung, and blood
diseases; blood resources; sleep disorders leading toward a combined M.D./Ph.D.
degree. Training under this award is designed to provide a foundation for
a career as a
physician-scientist in the areas of
interest to the NHLBI.
Predoctoral Individual NRSA (F31): To provide
predoctoral individuals with supervised research training in areas related to
heart, lung, and blood diseases; blood resources; and sleep disorders leading
toward the research degree (e.g., Ph.D.).
Postdoctoral Individual NRSA (F32): To provide
postdoctoral research training to individuals to broaden their scientific
background and extend their potential for research in areas related to heart,
lung, and blood diseases and blood resources.
NRSA for Senior Fellows (F33): To provide
experienced scientists with an opportunity to make major changes in the
direction of their research careers, to broaden their scientific background, to
acquire new research capabilities, to enlarge their command of an allied
research field, or to take time from regular professional responsibilities for
the purpose of broadening their research capabilities.
Institutional National Research Service Awards (NRSA)
Institutional NRSA (T32): To enable institutions
to make awards to individuals selected by them for predoctoral and postdoctoral
research training in areas related to heart, lung, and blood diseases; blood
resources; and sleep disorders.
Minority Institutional Research Training Program (T32M): To support full-time research training for investigative careers at
minority schools in areas of cardiovascular, pulmonary, and
hematologic diseases and sleep disorders. Graduate students, postdoctoral
students, or health professions students may be supported under this
program.
MARC Undergraduate NRSA Institutional Grants (T34): To support institutional training grants for underrepresented minority
undergraduates to obtain research training and improve their preparation for
graduate training in the biomedical and behavioral sciences.
NRSA Short-Term Research Training (T35 and T35M): To provide individuals with research training during off-quarters or
summer periods to encourage research careers or to encourage research in areas
of national need. This program includes the Short-Term Training for
Minority Students Program and short-term training for students in health
professional schools.
MARC Visiting Professors for Minority Institutions (T36): To increase the number of well-trained minority scientists in
biomedical disciplines and to strengthen the research and teaching
capabilities of minority institutions.
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Other Support
Research and Development Contracts (N01): To
develop or apply new knowledge or test, screen, or evaluate a product,
material, device, or component for use by the scientific community.
Small Business Innovation Research (N43): To
support projects, limited in time and amount, to establish the technical merit
and feasibility of R&D ideas that may ultimately lead to a commercial
product(s) or service(s).
NIH Inter-Agency Agreements (Y01): To provide a
source of funds to another Federal Agency to acquire specific products,
services, or studies.
NIH Intra-Agency Agreements (Y02): To provide a
source of funds to another NIH component to acquire specific products,
services, or studies.
Minority Research Supplements Programs: To
provide supplemental funds to active NHLBI grants to support the research of
minority high school, undergraduate, and graduate students; postdoctoral
trainees; and investigators.
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