Types of Research Activity
Research Projects
Research Project Grants (R01): To
support discrete and specific projects to be performed by one or several
investigators in areas of the investigator's particular interests and
competencies.
Research Projects (Cooperative Agreements)
(U01): To support discrete, circumscribed projects in areas of an
investigator's specific interest and competency involving substantial
programmatic participation by the NHLBI during performance of the activity.
Research Program (Cooperative Agreement)
(U10): To support a research program of multiple projects, requiring a
broadly-based, multidisciplinary and often long-term approach, directed toward
a specific major objective, common theme, or program goal relevant to the
Institute's mission. The award involves substantial programmatic
involvement by NHLBI staff to assist investigators during performance of the
research activities.
Research Program Projects (P01): To
support broadly based, multidisciplinary, often long-term research projects
that have specific major objectives or basic themes directed toward a
well-defined research program goal. Usually, a relatively large, organized
group of researchers conducts individual subprojects, the results of which help
achieve objectives of the program project.
Small Research Grants (R03): To
provide limited support for extended analyses of research data generated by
clinical trials, population research, and demonstration and education
studies.
Academic Research Enhancement Awards (AREA)
(R15): To support small-scale research projects conducted by faculty
in primarily baccalaureate degree-granting domestic institutions. Awards
are for up to $75,000 for direct costs (plus applicable indirect costs) for
periods not to exceed 36 months.
Exploratory/Developmental Grants
(R21): To encourage the development of new research activities in
heart, lung, and blood diseases and sleep disorders program areas.
Exploratory/Developmental Grant
(R33): To pro-vide phase II support for innovative exploratory and
developmental research activities initiated under the R21 mechanism.
Clinical Trial Planning Grant (R34): To
support the initial development of a clinical trial, including establishment of
the research team; development of tools for data management and oversight of
the research; development of a trial design and other essential elements of the
study, such as the protocol, recruitment strategies, and procedure manuals; and
to collect feasibility data.
Clinical Planning Grant Cooperative Agreement
(U34): To support the initial development of a clinical trial,
including establishment of the research team; development of tools for data
management and oversight of the research; development of a trial design and
other essential elements of the study, such as the protocol, recruitment
strategies, and procedure manuals; and to collect feasibility
data. The award involves substantial programmatic involvement by NHLBI
staff to assist investigators during performance of the research
activities.
Method To Extend Research in Time (MERIT)
Award (R37): To provide long-term research grant support to
investigators whose research competency and productivity are distinctly
superior and thus are likely to continue to perform in an outstanding
manner. Investigators may not apply for a MERIT award; instead, they are
selected by the NHLBI on the basis of their current grant applications and
their present and past grant support.
NIH Director's Pioneer Award (DP1):
To support individual scientists of exceptional creativity who propose
pioneering approaches to major contemporary challenges in biomedical
research.
NIH Director's New Innovator Award
(DP2): To support exceptionally creative new investigators who propose
highly innovative approaches that have the potential to produce an unusually
high impact. The New Innovator Award will emphasize the importance and
potential impact of the scientific problem, the novelty and innovativeness of
the approach, and the applicant's potential for creative and innovative
research.
Linked Research Project Grant (RL1): To
support a discrete, specified, circumscribed project that is administratively
linked to another project or projects.
Small Business Technology Transfer (STTR)
Grants—Phase I (R41): To support cooperative R&D projects
between small business concerns and research institutions, limited in time and
amount, to establish the technical merit and feasibility of ideas that have
potential for commercialization. Awards are made to small business
concerns only.
Small Business Technology Transfer (STTR)
Grants—Phase II (R42): To support in-depth development of
cooperative R&D projects between small business concerns and research
institutions, limited in time and amount, whose feasibility has been
established in phase I and that have potential for
commercialization. Awards are made to small business concerns only.
Small Business Innovation Research (SBIR)
Grants, Phase I (R43): To support projects, limited in time and
amount, to establish the technical merit and feasibility of research and
development ideas that may ultimately lead to commercial products or
services.
Small Business Innovation Research (SBIR)
Grants, Phase II (R44): To support research project ideas that have
been shown to be feasible in phase I and that are likely to result in
commercially marketable products or services.
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Research Centers
Exploratory Grants (P20): To support
planning for new programs, expansion or modification of existing resources, and
feasibility studies to explore various approaches to the development of
interdisciplinary programs that offer potential solutions to problems of
special significance to the mission of the NHLBI.
Center Core Grants (P30): To support
shared resources and facilities for basic, clinical, behavioral, and
translational research in the prevention, detection, and treatment of HIV
infection and AIDS.
Specialized Centers of Clinically Oriented
Research (SCCOR) Grants (P50): To foster multidisciplinary research on
clinically relevant questions enabling basic science findings to be applied
more rapidly to clinical problems. Research focuses on clinical and basic
scientific issues related to diseases and disorders that are relevant to the
mission of the NHLBI. The SCCOR program places more emphasis on clinical
research than the SCOR program and requires at least 50 percent of the funded
projects to be clinical.
Comprehensive Specialized Research Center
Grants (U54): To support a large, interrelated biomedical research
program focused on a disorder within the Institute's mandate; to initiate and
expand community education, screening, and counseling programs; and to educate
medical and allied health professionals concerning problems of diagnosis and
treatment of specific diseases such as sickle cell anemia.
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Research Career Programs
Mentored Research Scientist Development Award
for Minority Faculty (K01): To support underrepresented minority
faculty members with varying levels of research experience to prepare them for
research careers as independent investigators.
Mentored Scientist Development Award in
Research Ethics (K01): To provide support for training in research
ethics for health professionals working at academic and other health-related
institutions in biomedical, behavioral, or public health research, particularly
research involving human participants.
Minority Institution Faculty Mentored Research
Scientist Development Award (K01): To support faculty members at
minority institutions who have the interest and potential to conduct
state-of-the-art research in cardiovascular, pulmonary, or hematologic disease
or in sleep disorders.
Independent Scientist Award (K02): To
enhance the research capability of promising individuals in the formative
stages of their careers of independent research in the sciences related to
heart, lung, and blood diseases; blood resources; and sleep disorders.
Academic Award (K07): To support an
individual with an academic appointment to introduce or improve a disease
curriculum that will enhance the academic or research environment of the
applicant institution as well as further the individual's own career. This
award series included the Systemic Pulmonary and Vascular Diseases Academic
Awards, the Tuberculosis Academic Award, the Sleep Academic Award, and the
Nutrition Academic Award. Currently, the Cultural Competence and Health
Disparities Academic Award and the Pediatric Transfusion Medicine
Academic Award programs are being supported.
Clinical Investigator Development Award
(K08): To provide an opportunity for clinically trained physicians to
develop research skills and gain experience in advanced research methods
and experimental approaches in basic and applied sciences relevant to
cardiovascular, pulmonary, and hematological diseases.
Research Career Development Program in
Vascular Medicine (K12): To promote comprehensive clinical research
training for physicians wanting to specialize in vascular medicine. The
goal is to prepare clinicians for academic roles in mentoring and leadership in
clinical research in vascular medicine.
Research Career Development Program in
Clinical Hematology (K12): To develop and evaluate
multidisciplinary career development programs in clinical hematology
research that will equip new academic researchers with the knowledge and skills
to address complex problems in blood diseases, transfusion medicine, and
cellular therapies.
Research Career Development Program in the
Genetics and Genomics of Lung Diseases (K12): To develop
multidisciplinary career development programs in genetics and genomics of lung
diseases that will equip new investigators with the knowledge and skills to
elucidate the etiology and pathogenesis of such diseases.
Career Enhancement Award for Stem Cell
Research (K18): To enable established investigators to acquire new
research capabilities in the use of human or animal embryonic, adult, or cord
blood stem cells. All candidates must have a sponsor, either within their
own or at another institution, who is a well-qualified stem cell expert to
serve as a mentor.
NHLBI Career Transition Award (K22):
To support the postdoctoral research training of an outstanding individual in
an NHLBI intramural laboratory for up to 3 years and subsequently, to support
the individual's successful transition from postdoctoral research to an
extramural environment as an independent researcher.
Mentored Patient-Oriented Research Career
Development Award (K23): To provide support for career development to
investigators who have made a commitment to focus their research endeavors on
patient-oriented research.
Midcareer Investigator Award in
Patient-Oriented Research (K24): To provide support for clinicians to
allow them "protected time" to devote to patient-oriented research
and to act as mentors for beginning clinical investigators.
Mentored Quantitative Research Career
Development Award (K25): To provide support to investigators with
quantitative science or engineering backgrounds who have made a commitment to
focus their research on basic or clinical biomedicine, bioengineering,
bioimaging, or behavioral sciences.
Pathway to Independence (K99/R00): To
provide up to 5 years support in two phases to highly promising postdoctoral
scientists to pursue research relevant to the Institute. The K99 phase
consists of 1 to 2 years mentored support followed by up to 3 years of
independent support (R00) contingent on securing an independent research
position. Award recipients will be expected to compete successfully for
independent research grant support from the NIH or other Institutions during
the independence phase to ensure continued support and a smooth transition to
independence.
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Other Research Grants
Scientific Evaluation (R09): To
provide funds to the chairman of an initial review group for operation of the
review group.
Cooperative Clinical Research (R10)
(U10): To support studies and evaluations of relevant clinical
problems. These grants usually involve collaborative efforts among several
institutions and principal investigators and are conducted under a formal
protocol.
Conference Grants (R13): To support
national and international scientific meetings, conferences, or workshops at
which research is discussed.
Research Demonstration and Education Projects
(R18): To provide support designed to develop, test, and evaluate
health-related activities and to foster application of existing knowledge to
the control of heart, lung, and blood diseases and sleep disorders.
Resource-Related Research Projects
(R24): To support research projects that will enhance the capability
of resources to serve biomedical research in areas related to cardiovascular,
lung, and blood health and diseases; blood resources; and sleep
disorders.
Education Projects (R25): To provide
support for the development and implementation of a program as it relates to a
category in one or more of the areas of education, information, training,
technical assistance, coordination, or evaluation.
Minority Biomedical Research Support Grants
(S06): To strengthen the biomedical research and research training
capability of minority institutions and to assist in increasing the involvement
of minority faculty and students in biomedical research.
Research Enhancement Award (SC1): To
support individual investigator-initiated research projects aimed at developing
researchers at minority-serving institutions to a stage where they can
transition successfully to other extramural support.
Pilot Project Award (SC2): To support
underrepresented minorities who are at the beginning stages of a research
career and interested in testing a new idea or generating preliminary data, or
who are more experienced investigators and interested in switching to a
different field of research.
Continuing Education Training Grant
(T15): To assist professional schools and other public and nonprofit
institutions to establish, expand, or improve programs of continuing
professional education, especially for programs dealing with new scientific
developments.
Resource-Related Research Projects
(U24): To support research projects contributing to improvement of the
capability of resources to serve biomedical research.
National Swine Research and Resource Center
(U42): To support a National Swine Research and Resource Center that
will serve as a resource for depositing, maintaining, preserving, and
distributing swine models for studies of human diseases, as well as
cryopreservation, storage, and reconstitution of embryos and germplasm.
Historical Black College and University
Scientist Award (UH1): To strengthen and augment the human resources
at historically black colleges and universities (HBCU) by recruiting an
established research scientist into their biomedical or behavioral sciences
department; to enhance the career of the recruited research scientist; and to
strengthen other HBCU resources for the conduct of biomedical or behavioral
research in areas related to cardiovascular, lung, and blood health and
disease; transfusion medicine; and sleep disorders.
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Individual National Research
Service Awards (NRSA)
Individual Predoctoral M.D./Ph.D. NRSA
(F30): To provide predoctoral individuals with supervised research
training in areas related to heart, lung, and blood diseases; blood resources;
sleep disorders leading toward a combined M.D./Ph.D. degree. Training
under this award is designed to provide a foundation for a career as a
physician-scientist in the areas of interest to the NHLBI.
Predoctoral Individual NRSA (F31): To
provide pre-doctoral individuals with supervised research training in areas
related to heart, lung, and blood diseases; blood resources; and sleep
disorders leading toward the research degree (e.g., Ph.D.).
Postdoctoral Individual NRSA (F32):
To provide postdoctoral research training to individuals to broaden their
scientific background and extend their potential for research in areas related
to heart, lung, and blood diseases and blood resources.
NRSA for Senior Fellows (F33): To
provide experienced scientists with an opportunity to make major changes in the
direction of their research careers, to broaden their scientific background, to
acquire new research capabilities, to enlarge their command of an allied
research field, or to take time from regular professional responsibilities for
the purpose of broadening their research capabilities.
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Institutional National
Research Service Awards (NRSA)
Institutional NRSA (T32): To enable
institutions to make awards to individuals selected by them for predoctoral and
postdoctoral research training in areas related to heart, lung, and blood
diseases; blood resources; and sleep disorders.
Minority Institutional Research Training
Program (T32M): To support full-time research training for
investigative careers at minority schools in areas of
cardiovascular, pulmonary, and hematologic diseases and sleep
disorders. Graduate students, postdoctoral students, or health
professions students may be supported under this program.
MARC Undergraduate NRSA Institutional Grants
(T34): To support institutional training grants for underrepresented
minority undergraduates to obtain research training and improve their
preparation for graduate training in the biomedical and behavioral
sciences.
NRSA Short-Term Research Training (T35 and
T35M): To provide individuals with research training during
off-quarters or summer periods to encourage research careers or to encourage
research in areas of national need. This program includes the Short-Term
Training for Minority Students Program and short-term training for students in
health professional schools.
MARC Visiting Professors for Minority
Institutions (T36): To increase the number of well-trained minority
scientists in biomedical disciplines and to strengthen the research and
teaching capabilities of minority institutions.
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Other Support
Research and Development Contracts
(N01): To develop or apply new knowledge or test, screen, or evaluate
a product, material, device, or component for use by the scientific
community.
Small Business Innovation Research
(N43): To support projects, limited in time and amount, to establish
the technical merit and feasibility of R&D ideas that may ultimately lead
to a commercial product(s) or service(s).
NIH Inter-Agency Agreements (Y01): To
provide a source of funds to another Federal Agency to acquire specific
products, services, or studies.
NIH Intra-Agency Agreements (Y02): To
provide a source of funds to another NIH component to acquire specific
products, services, or studies.
Minority Research Supplements
Programs: To provide supplemental funds to active NHLBI grants to
support the research of minority high school, undergraduate, and graduate
students; postdoctoral trainees; and investigators.
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