Types of Research Activity
Research Projects
Research Project Grants (R01):
To support discrete and specific projects to be performed by one or
several investigators in areas of the investigator's particular interests and
competencies.
Research Projects (Cooperative Agreements)
(U01): To support discrete, circumscribed projects in areas of
an investigator's specific interest and competency involving substantial
programmatic participation by the NHLBI during performance of the activity.
Research Program (Cooperative Agreement)
(U10): To support a research program of multiple projects,
requiring a broadly-based, multidisciplinary and often long-term approach,
directed toward a specific major objective, common theme, or program goal
relevant to the Institute's mission. The award involves substantial
programmatic involvement by NHLBI staff to assist investigators during
performance of the research activities.
Research Program Projects (P01):
To support broadly based, multidisciplinary, often long-term research
projects that have specific major objectives or basic themes directed toward a
well-defined research program goal. Usually, a relatively large,
organized group of researchers conducts individual subprojects, the results of
which help achieve objectives of the program project.
Small Research Grants (R03): To
provide limited support for extended analyses of research data generated by
clinical trials, population research, and demonstration and education
studies.
Academic Research Enhancement Awards (AREA)
(R15): To support small-scale research projects conducted by
faculty in primarily baccalaureate degree-granting domestic institutions.
Awards are for up to $75,000 for direct costs (plus applicable indirect costs)
for periods not to exceed 36 months.
Exploratory/Developmental Grants (R21):
To encourage the development of new research activities in heart,
lung, and blood diseases and sleep disorders program areas.
Exploratory/Developmental Grant (R33):
To provide phase II support for innovative exploratory and
developmental research activities initiated under the R21 mechanism.
Method To Extend Research in Time (MERIT)
Award (R37): To provide long-term research grant support to
investigators whose research competency and productivity are distinctly
superior and thus are likely to continue to perform in an outstanding
manner. Investigators may not apply for a MERIT award; instead, they are
selected by the NHLBI on the basis of their current grant applications and
their present and past grant support.
NIH Director's Pioneer Award (DP1):
To support individual scientists of exceptional creativity who propose
pioneering approaches to major contemporary challenges in biomedical
research.
NIH Director's New Innovator Award
(DP2): To support exceptionally creative new investigators who
propose highly innovative approaches that have the potential to produce an
unusually high impact. The New Innovator Award will emphasize the
importance and potential impact of the scientific problem, the novelty and
innovativeness of the approach, and the applicant's potential for creative and
innovative research.
Small Business Technology Transfer (STTR)
Grants—Phase I (R41): To support cooperative R&D
projects between small business concerns and research institutions, limited in
time and amount, to establish the technical merit and feasibility of ideas that
have potential for commercialization. Awards are made to small business
concerns only.
Small Business Technology Transfer (STTR)
Grants—Phase II (R42): To support in-depth development of
cooperative R&D projects between small business concerns and research
institutions, limited in time and amount, whose feasibility has been
established in phase I and that have potential for commercialization.
Awards are made to small business concerns only.
Small Business Innovation Research (SBIR)
Grants, Phase I (R43): To support projects, limited in time and
amount, to establish the technical merit and feasibility of research and
development ideas that may ultimately lead to commercial products or
services.
Small Business Innovation Research (SBIR)
Grants, Phase II (R44): To support research project ideas that
have been shown to be feasible in phase I and that are likely to result in
commercially marketable products or services.
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Research Centers
Exploratory Grants (P20): To
support planning for new programs, expansion or modification of existing
resources, and feasibility studies to explore various approaches to the
development of interdisciplinary programs that offer potential solutions to
problems of special significance to the mission of the NHLBI.
Center Core Grants (P30): To
support shared resources and facilities for basic, clinical, behavioral, and
translational research in the prevention, detection, and treatment of HIV
infection and AIDS.
Animal (Mammalian and Nonmammalian) Model and
Animal and Material Resource Grant (P40): To develop and support
animal models, or animal or biological materials resources. Nonmammalian
resources include nonmammalian vertebrates, invertebrates, cell systems, and
nonbiological systems.
Specialized Centers of Clinically Oriented
Research (SCCOR) Grants (P50): To foster multidisciplinary
research on clinically relevant questions enabling basic science findings to be
applied more rapidly to clinical problems. Research focuses on clinical
and basic scientific issues related to diseases and disorders that are relevant
to the mission of the NHLBI. The SCCOR program places more emphasis on
clinical research than the SCOR program and requires at least 50 percent of the
funded projects to be clinical.
Comprehensive Specialized Research Center
Grants (U54): To support a large, interrelated biomedical
research program focused on a disorder within the Institute's mandate; to
initiate and expand community education, screening, and counseling programs;
and to educate medical and allied health professionals concerning problems of
diagnosis and treatment of specific diseases such as sickle cell anemia.
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Research Career Programs
Mentored Research Scientist Development Award
for Minority Faculty (K01): To support underrepresented minority
faculty members with varying levels of research experience to prepare them for
research careers as independent investigators.
Mentored Scientist Development Award in
Research Ethics (K01): To provide support for training in
research ethics for health professionals working at academic and other
health-related institutions in biomedical, behavioral, or public health
research, particularly research involving human participants.
Minority Institution Faculty Mentored Research
Scientist Development Award (K01): To support faculty members at
minority institutions who have the interest and potential to conduct
state-of-the-art research in cardiovascular, pulmonary, or hematologic disease
or in sleep disorders.
Independent Scientist Award (K02):
To enhance the research capability of promising individuals in the
formative stages of their careers of independent research in the sciences
related to heart, lung, and blood diseases; blood resources; and sleep
disorders.
Research Career Development Award (K04):
To foster the development of young scientists with outstanding
research potential for careers of independent research in the sciences related
to heart, lung, and blood diseases and blood resources. New grants are no
longer awarded.
Research Career Award (K06): To
assist institutions in supporting established investigators of high competency
for the duration of their careers. New grants are no longer awarded.
Academic Award (K07): To
support an individual with an academic appointment to introduce or improve a
disease curriculum that will enhance the academic or research environment of
the applicant institution as well as further the individual's own career.
This award series included the Systemic Pulmonary and Vascular Diseases
Academic Awards, the Asthma Academic Award, the Tuberculosis Academic Award,
the Sleep Academic Award, and the Nutrition Academic Award. Currently,
the Cultural Competence and Health Disparities Academic Award and the Pediatric
Transfusion Medicine Academic Award programs are being supported.
Clinical Investigator Development Award
(K08): To provide an opportunity for clinically trained
physicians to develop research skills and gain experience in advanced research
methods and experimental approaches in basic and applied sciences relevant to
cardiovascular, pulmonary, and hematological diseases.
Research Career Development Program in
Vascular Medicine (K12): To promote comprehensive clinical
research training for physicians wanting to specialize in vascular
medicine. The goal is to prepare clinicians for academic roles in
mentoring and leadership in clinical research in vascular medicine.
Research Career Development Program in
Clinical Hematology (K12): To develop and evaluate
multidisciplinary career development programs in clinical hematology research
that will equip new academic researchers with the knowledge and skills to
address complex problems in blood diseases, transfusion medicine, and cellular
therapies.
Research Career Development Program in the
Genetics and Genomics of Lung Diseases (K12): To develop
multidisciplinary career development programs in genetics and genomics of lung
diseases that will equip new investigators with the knowledge and skills to
elucidate the etiology and pathogenesis of such diseases.
Minority School Faculty Development Award
(K14): To develop faculty investigators at minority schools and
enhance their research capabilities in areas related to heart, lung, and blood
diseases; blood resources; and sleep disorders. New grants are no longer
awarded.
Research Development Award for Minority
Faculty (K14): To encourage the development of minority faculty
investigators and enhance their research capabilities in areas related to
cardiovascular, lung, and blood health and disease; transfusion medicine; and
sleep disorders. New grants are no longer awarded.
Career Enhancement Award for Stem Cell
Research (K18): To enable established investigators to acquire
new research capabilities in the use of human or animal embryonic, adult, or
cord blood stem cells. All candidates must have a sponsor, either within
their own or at another institution, who is a well-qualified stem cell expert
to serve as a mentor.
NHLBI Career Transition Award (K22):
To support the postdoctoral research training of an outstanding
individual in an NHLBI intramural laboratory for up to 3 years and
subsequently, to support the individual's successful transition from
postdoctoral research to an extramural environment as an independent
researcher.
Mentored Patient-Oriented Research Career
Development Award (K23): To provide support for career
development to investigators who have made a commitment to focus their research
endeavors on patient-oriented research.
Midcareer Investigator Award in
Patient-Oriented Research (K24): To provide support for
clinicians to allow them “protected time” to devote to
patient-oriented research and to act as mentors for beginning clinical
investigators.
Mentored Quantitative Research Career
Development Award (K25): To provide support to investigators
with quantitative science or engineering backgrounds who have made a commitment
to focus their research on basic or clinical biomedicine, bioengineering,
bioimaging, or behavioral sciences.
Clinical Research Curriculum Award (CRCA)
(K30): To stimulate inclusion of high-quality, multidisciplinary
didactic training in fundamental skills, methodology, theories, and
conceptualization as part of the career development of clinical
investigators.
Career Transition Award (K99/R00):
To provide up to 5 years support in two phases to highly promising
postdoctoral scientists to pursue research relevant to the Institute. The
K99 phase consists of 1 to 2 years mentored support followed by up to 3 years
of independent support (R00) contingent on securing an independent research
position. Award recipients will be expected to compete successfully for
independent research grant support from the NIH or other Institutions during
the independence phase to ensure continued support and a smooth transition to
independence.
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Other Research Grants
Scientific Evaluation (R09): To
provide funds to the chairman of an initial review group for operation of the
review group.
Cooperative Clinical Research (R10)
(U10): To support studies and evaluations of relevant clinical
problems. These grants usually involve collaborative efforts among
several institutions and principal investigators and are conducted under a
formal protocol.
Conference Grants (R13): To
support national and international scientific meetings, conferences, or
workshops at which research is discussed.
Research Demonstration and Education Projects
(R18): To provide support designed to develop, test, and
evaluate health-related activities and to foster application of existing
knowledge to the control of heart, lung, and blood diseases and sleep
disorders.
Resource-Related Research Projects
(R24): To support research projects that will enhance the
capability of resources to serve biomedical research in areas related to
cardiovascular, lung, and blood health and diseases; blood resources; and sleep
disorders.
Education Projects (R25): To
provide support for the development and implementation of a program as it
relates to a category in one or more of the areas of education, information,
training, technical assistance, coordination, or evaluation.
Minority Biomedical Research Support Grants
(S06): To strengthen the biomedical research and research training
capability of minority institutions and to assist in increasing the involvement
of minority faculty and students in biomedical research.
Pilot Project Award (SC2): To
support underrepresentative minorities who are at the beginning stages of a
research career and interested in testing a new idea or generating preliminary
data, or who are more experienced investigators and interested in switching to
a different field of research.
Continuing Education Training Grant
(T15): To assist professional schools and other public and
nonprofit institutions to establish, expand, or improve programs of continuing
professional education, especially for programs dealing with new scientific
developments.
Scientific Review and Evaluation (U09):
To support an initial Scientific Review Group responsible for the
assessment of scientific and technical merit of grant applications.
Resource-Related Research Projects
(U24): To support research projects contributing to improvement
of the capability of resources to serve biomedical research.
National Swine Research and Resource Center
(U42): To support a National Swine Research and Resource Center
that will serve as a resource for depositing, maintaining, preserving, and
distributing swine models for studies of human diseases, as well as
cryopreservation, storage, and reconstitution of embryos and germplasm.
Historical Black College and University
Scientist Award (UH1): To strengthen and augment the human
resources at historically black colleges and universities (HBCU) by recruiting
an established research scientist into their biomedical or behavioral sciences
department; to enhance the career of the recruited research scientist; and to
strengthen other HBCU resources for the conduct of biomedical or behavioral
research in areas related to cardiovascular, lung, and blood health and
disease; transfusion medicine; and sleep disorders.
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Individual National Research
Service Awards (NRSA)
Individual Predoctoral M.D./Ph.D. NRSA
(F30): To provide predoctoral individuals with supervised
research training in areas related to heart, lung, and blood diseases; blood
resources; sleep disorders leading toward a combined M.D./Ph.D. degree.
Training under this award is designed to provide a foundation for a career as a
physician-scientist in the areas of interest to the NHLBI.
Predoctoral Individual NRSA (F31):
To provide predoctoral individuals with supervised research training
in areas related to heart, lung, and blood diseases; blood resources; and sleep
disorders leading toward the research degree (e.g., Ph.D.).
Postdoctoral Individual NRSA (F32):
To provide postdoctoral research training to individuals to broaden
their scientific background and extend their potential for research in areas
related to heart, lung, and blood diseases and blood resources.
NRSA for Senior Fellows (F33):
To provide experienced scientists with an opportunity to make major
changes in the direction of their research careers, to broaden their scientific
background, to acquire new research capabilities, to enlarge their command of
an allied research field, or to take time from regular professional
responsibilities for the purpose of broadening their research capabilities.
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Institutional National
Research Service Awards (NRSA)
Institutional NRSA (T32): To
enable institutions to make awards to individuals selected by them for
predoctoral and postdoctoral research training in areas related to heart, lung,
and blood diseases; blood resources; and sleep disorders.
Minority Institutional Research Training
Program (T32M): To support full-time research training for
investigative careers at minority schools in areas of cardiovascular,
pulmonary, and hematologic diseases and sleep disorders. Graduate
students, postdoctoral students, or health professions students may be
supported under this program.
MARC Undergraduate NRSA Institutional Grants
(T34): To support institutional training grants for
underrepresented minority undergraduates to obtain research training and
improve their preparation for graduate training in the biomedical and
behavioral sciences.
NRSA Short-Term Research Training (T35 and
T35M): To provide individuals with research training during
off-quarters or summer periods to encourage research careers or to encourage
research in areas of national need. This program includes the Short-Term
Training for Minority Students Program and short-term training for students in
health professional schools.
MARC Visiting Professors for Minority
Institutions (T36): To increase the number of well-trained
minority scientists in biomedical disciplines and to strengthen the research
and teaching capabilities of minority institutions.
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Other Support
Research and Development Contracts
(N01): To develop or apply new knowledge or test, screen, or
evaluate a product, material, device, or component for use by the scientific
community.
Small Business Innovation Research
(N43): To support projects, limited in time and amount, to
establish the technical merit and feasibility of R&D ideas that may
ultimately lead to a commercial product(s) or service(s).
NIH Inter-Agency Agreements (Y01):
To provide a source of funds to another Federal Agency to acquire
specific products, services, or studies.
NIH Intra-Agency Agreements (Y02):
To provide a source of funds to another NIH component to acquire
specific products, services, or studies.
Minority Research Supplements Programs:
To provide supplemental funds to active NHLBI grants to support the
research of minority high school, undergraduate, and graduate students;
postdoctoral trainees; and investigators.
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