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Types of Research Activity
Research Projects
Research Project Grants (R01):
To support discrete and specific projects to be performed by one or several
investigators in areas of the investigator’s particular interests and
competencies.
Research Projects (Cooperative Agreements)
(U01): To support discrete, circumscribed projects in areas of
an investigator’s specific interest and competency involving substantial
programmatic participation by the NHLBI during performance of the activity.
Research Program Projects
(P01): To support broadly based, multidisciplinary, often
long-term research projects that have specific major objectives or basic themes
directed toward a well-defined research program goal. Usually, a
relatively large, organized group of researchers conducts individual
subprojects, the results of which help achieve objectives of the program
project.
Small Research Grants (R03): To
provide limited support for extended analyses of research data generated by
clinical trials, population research, and demonstration and education
studies.
Academic Research Enhancement Awards (AREA)
(R15): To support small-scale research projects conducted by
faculty in primarily baccalaureate degree-granting domestic institutions.
Awards are for up to $75,000 for direct costs (plus applicable indirect costs)
for periods not to exceed 36 months.
Exploratory/Developmental Grants
(R21): To encourage the development of new research activities
in heart, lung, and blood diseases and sleep disorders program areas.
First Independent Research Support and
Transition (FIRST) Award (R29): To provide a sufficient initial
period of research support for newly independent biomedical investigators to
develop their research capabilities and demonstrate the merit of their research
ideas. New grants are no longer awarded.
Exploratory/Developmental Grant
(R33): To provide phase II support for innovative exploratory
and developmental research activities initiated under the R21 mechanism.
Method To Extend Research in Time (MERIT)
Award (R37): To provide long-term research grant support to
investigators whose research competency and productivity are distinctly
superior and thus are likely to continue to perform in an outstanding
manner. Investigators may not apply for a MERIT award; instead, they are
selected by the NHLBI on the basis of their current grant applications and
their present and past grant support.
NIH Director’s Pioneer Award (DP1):
To support individual scientists of exceptional creativity who propose
pioneering approaches to major contemporary challenges in biomedical
research.
Small Business Technology Transfer (STTR)
Grants—Phase I (R41): To support cooperative R&D
projects between small business concerns and research institutions, limited in
time and amount, to establish the technical merit and feasibility of ideas that
have potential for commercialization. Awards are made to small business
concerns only.
Small Business Technology Transfer (STTR)
Grants—Phase II (R42): To support in-depth development of
cooperative R&D projects between small business concerns and research
institutions, limited in time and amount, whose feasibility has been
established in phase I and that have potential for commercialization.
Awards are made to small business concerns only.
Small Business Innovation Research (SBIR)
Grants, Phase I (R43): To support projects, limited in time and
amount, to establish the technical merit and feasibility of research and
development ideas that may ultimately lead to commercial products or
services.
Small Business Innovation Research (SBIR)
Grants, Phase II (R44): To support research project ideas that
have been shown to be feasible in phase I and that are likely to result in
commercially marketable products or services.
Research Centers
Exploratory Grants (P20): To
support planning for new programs, expansion or modification of existing
resources, and feasibility studies to explore various approaches to the
development of interdisciplinary programs that offer potential solutions to
problems of special significance to the mission of the NHLBI.
Center Core Grants (P30): To
support shared resources and facilities for basic, clinical, behavioral, and
translational research in the prevention, detection, and treatment of HIV
infection and AIDS.
Animal (Mammalian and Nonmammalian) Model and
Animal and Material Resource Grant (P40): To develop and support
animal models, or animal or biological materials resources. Nonmammalian
resources include nonmammalian vertebrates, invertebrates, cell systems, and
nonbiological systems.
Specialized Centers of Research (SCOR) Grants
(P50): To support both basic and clinical research related to an
Institute-identified theme. The spectrum of SCOR activities comprises
multidisciplinary approaches to specific disease entities or biomedical problem
areas. The SCOR grants differ from research program projects in that they
are in response to an announcement of programmatic needs of the
Institute. Centers may be asked to perform additional studies because of
urgently needed information or may serve as a regional or national resource for
special purpose research.
Comprehensive Specialized Research Center
Grants (U54): To support a large, interrelated biomedical
research program focused on a disorder within the Institute’s mandate; to
initiate and expand community education, screening, and counseling programs;
and to educate medical and allied health professionals concerning problems of
diagnosis and treatment of specific diseases such as sickle cell anemia.
Research Career Programs
Mentored Research Scientist Development Award
for Minority Faculty (K01): To support underrepresented minority
faculty members with varying levels of research experience to prepare them for
research careers as independent investigators.
Mentored Scientist Development Award in
Research Ethics (K01): To provide support for training in
research ethics for health professionals working at academic and other
health-related institutions in biomedical, behavioral, or public health
research, particularly research involving human participants.
Minority Institution Faculty Mentored Research
Scientist Development Award (K01): To support faculty members at
minority institutions who have the interest and potential to conduct
state-of-the-art research in cardiovascular, pulmonary, or hematologic disease,
or in sleep disorders.
Independent Scientist Award
(K02): To enhance the research capability of promising
individuals in the formative stages of their careers of independent research in
the sciences related to heart, lung, and blood diseases; blood resources; and
sleep disorders.
Research Career Development Award
(K04): To foster the development of young scientists with
outstanding research potential for careers of independent research in the
sciences related to heart, lung, and blood diseases and blood resources.
New grants are no longer awarded.
Research Career Award (K06): To
assist institutions in supporting established investigators of high competency
for the duration of their careers. New grants are no longer awarded.
Academic Award (K07): To
support an individual with an academic appointment to introduce or improve a
disease curriculum that will enhance the academic or research environment of
the applicant institution as well as further the individual’s own
career. This award series includes the Preventive Cardiology Academic
Award, the Preventive Pulmonary Academic Award, the Transfusion Medicine
Academic Award, and the Systemic Pulmonary and Vascular Diseases Academic
Awards, the Asthma Academic Award, the Tuberculosis Academic Award, the Sleep
Academic Award, the Nutrition Academic Award, and the Cultural Competence and
Health Disparities Academic Award. Currently, the Cultural Competence and
Health Disparities Academic Award program is being supported.
Clinical Investigator Development Award
(K08): To provide an opportunity for clinically trained
physicians to develop research skills and gain experience in advanced research
methods and experimental approaches in basic and applied sciences relevant to
cardiovascular, pulmonary, and hematological diseases. This award was
developed to encourage clinical investigators to engage in research in specific
areas designated by the Institute.
Physician Scientist Award
(K11): To encourage newly trained clinicians to develop
independent research skills and experience in one of the fundamental
sciences. New grants are no longer awarded.
Research Career Development Program in
Vascular Medicine (12): To promote comprehensive clinical
research training for physicans wanting to specialize in vascular
medicine. The goal is to prepare clinicians for academic roles in
mentoring and leadership in clinical research in vascular medicine.
Research Career Development Program in
Clinical Hematology (12): To develop and evaluate
multidisciplinary career development programs in clinical hematology research
that will equip new academic researchers with the knowledge and skills to
address complex problems in blood diseases, transfusion medicine, and cellular
therapies.
Minority School Faculty Development Award
(K14): To develop faculty investigators at minority schools and
to enhance their research capabilities in areas related to heart, lung, and
blood diseases; blood resources; and sleep disorders. New grants are no
longer awarded.
Research Development Award for Minority
Faculty (K14): To encourage the development of minority faculty
investigators and to enhance their research capabilities in areas related to
cardiovascular, lung, and blood health and disease; transfusion medicine; and
sleep disorders. New grants are no longer awarded.
Career Enhancement Award for Stem Cell
Research (K18): To enable established investigators to acquire
new research capabilities in the use of human or animal embryonic, adult, or
cord blood stem cells. All candidates must have a sponsor, either within
their own or at another institution, who is a well-qualified stem cell expert
to serve as a mentor.
NHLBI Career Transition Award
(K22): To support the postdoctoral research training of an
outstanding individual in an NHLBI intramural laboratory for up to 3 years and
subsequently, to support the individual’s successful transition from
postdoctoral research to an extramural environment as an independent
researcher.
Mentored Patient-Oriented Research Career
Development Award (K23): To provide support for career
development to investigators who have made a commitment to focus their research
endeavors on patient-oriented research.
Midcareer Investigator Award in
Patient-Oriented Research (K24): To provide support for
clinicians to allow them “protected time” to devote to
patient-oriented research and to act as mentors for beginning clinical
investigators.
Mentored Quantitative Research Career
Development Award (K25): To provide support to investigators
with quantitative science or engineering backgrounds who have made a commitment
to focus their research on basic or clinical biomedicine, bioengineering,
bioimaging, or behavioral sciences.
Clinical Research Curriculum Award (CRCA)
(K30): To stimulate inclusion of high-quality, multidisciplinary
didactic training in fundamental skills, methodology, theories, and
conceptualization as part of the career development of clinical
investigators.
Other Research Grants
Scientific Evaluation (R09): To
provide funds to the chairman of an initial review group for operation of the
review group.
Resource-Related Research Projects
(R24): To support research projects that will enhance the
capability of resources to serve biomedical research in areas related to
cardiovascular, lung, and blood health and diseases; blood resources; and sleep
disorders.
Cooperative Clinical Research (R10)
(U10): To support studies and evaluations of relevant clinical
problems. These grants usually involve collaborative efforts among
several institutions and principal investigators and are conducted under a
formal protocol.
Conference Grants (R13): To
support national and international scientific meetings, conferences, or
workshops at which research is discussed.
Research Demonstration and Education Projects
(R18): To provide support designed to develop, test, and
evaluate health-related activities and to foster application of existing
knowledge to the control of heart, lung, and blood diseases and sleep
disorders.
Education Projects (R25): To
provide support for the development and implementation of a program as it
relates to a category in one or more of the areas of education, information,
training, technical assistance, coordination, or evaluation.
Minority Biomedical Research Support Grants
(S06) (S14): To strengthen the biomedical research and research
training capability of minority institutions and to assist in increasing the
involvement of minority faculty and students in biomedical research.
Biomedical Research Support Grants
(S07): To strengthen, balance, and stabilize supported
biomedical and behavioral research programs through flexible funds that permit
institutions to respond quickly and effectively to emerging needs and
opportunities; to enhance cre-ativity and innovation, to support pilot studies,
and to improve research resources.
Continuing Education Training Grant
(T15): To assist professional schools and other public and
nonprofit institutions to establish, expand, or improve programs of continuing
professional education, especially for programs dealing with new scientific
developments.
Scientific Review and Evaluation
(U09): To support an initial Scientific Review Group responsible
for the assessment of scientific and technical merit of grant applications.
Conference (Cooperative Agreements)
(U13): To support international, national, or regional meetings;
conferences; and workshops where substantial programmatic involvement is
planned to assist the recipient.
Resource-Related Research Projects
(U24): To support research projects contributing to improvement
of the capability of resources to serve biomedical research.
National Swine Research and Resource Center
(U42): To support a National Swine Research and Resource Center
that will serve as a resource for depositing, maintaining, preserving, and
distributing swine models for studies of human diseases, as well as
cryopreservation, storage, and reconstitution of embryos and germplasm.
Small Business Innovation Research Cooperative
Agreements (U44): To provide support for phase II and fast-track
projects that directly address identification and preclinical testing of new
therapeutics.
Historical Black College and University
Scientist Award (UH1): To strengthen and augment the human
resources at historically black colleges and universities (HBCU) by recruiting
an established research scientist into their biomedical or behavioral sciences
department; to enhance the career of the recruited research scientist; and to
strengthen other HBCU resources for the conduct of biomedical or behavioral
research in areas related to cardiovascular, lung, and blood health and
disease; transfusion medicine; and sleep disorders.
Individual National Research
Service Awards (NRSA)
Predoctoral Individual NRSA
(F31): To provide predoctoral individuals with supervised
research training in areas related to heart, lung, and blood diseases; blood
resources; and sleep disorders leading toward the research degree (e.g.,
Ph.D.).
Postdoctoral Individual NRSA
(F32): To provide postdoctoral research training to individuals
to broaden their scientific background and extend their potential for research
in areas related to heart, lung, and blood diseases and blood resources.
NRSA for Senior Fellows (F33):
To provide experienced scientists with an opportunity to make major changes in
the direction of their research careers, to broaden their scientific
background, to acquire new research capabilities, to enlarge their command of
an allied research field, or to take time from regular professional
responsibilities for the purpose of broadening their research capabilities.
Institutional National
Research Service Awards (NRSA)
Institutional NRSA (T32): To
enable institutions to make awards to individuals selected by them for
predoctoral and postdoctoral research training in areas related to heart, lung,
and blood diseases; blood resources; and sleep disorders.
Minority Institutional Research Training
Program (T32M): To support full-time research training for
investigative careers at minority schools in areas of cardiovascular,
pulmonary, and hematologic diseases and sleep disorders. Graduate
students, postdoctoral students, or health professions students may be
supported under this program.
MARC Undergraduate NRSA Institutional Grants
(T34): To support institutional training grants for
underrepresented minority undergraduates to obtain research training and
improve their preparation for graduate training in the biomedical and
behavioral sciences.
NRSA Short-Term Research Training (T35 and
T35S): To provide individuals with research training during
off-quarters or summer periods to encourage research careers or to encourage
research in areas of national need. This program includes the Short-Term
Training for Minority Students Program and short-term training for students in
health professional schools.
MARC Visiting Professors for Minority
Institutions (T36): To increase the number of well-trained
minority scientists in biomedical disciplines and to strengthen the research
and teaching capabilities of minority institutions.
Other Support
Research and Development Contracts
(N01): To develop or apply new knowledge or test, screen, or
evaluate a product, material, device, or component for use by the scientific
community.
Small Business Innovation Research
(N43): To support projects, limited in time and amount, to
establish the technical merit and feasibility of R&D ideas that may
ultimately lead to a commercial product(s) or service(s).
NIH Interagency Agreements
(Y01): To provide a source of funds to another Federal agency to
acquire specific products, services, or studies.
NIH Intra-Agency Agreements
(Y02): To provide a source of funds to another NIH component to
acquire specific products, services, or studies.
Minority Research Supplements
Programs: To provide supplemental funds to active NHLBI grants
to support the research of minority high school, undergraduate, and graduate
students; postdoctoral trainees; and investigators.
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