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10. Research and Development Contracts

• NHLBI Total Research and Development Contract Obligations: Fiscal Years 1995–2005
• Major NHLBI Research and Development Contracts by Program

NHLBI Research and Development Contract Obligations*: Fiscal Years 1995–2005

Text-only with data points

* For detailed data on contract-supported clinical trials, see Chapter 11.

NHLBI Total Research and Development Contract Obligations: Fiscal Years 1995–2005

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Major NHLBI Research and Development Contracts by Program

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Heart and Vascular Diseases Program

Atherosclerosis Risk in Communities (ARIC), Initiated in Fiscal Year 1985

The ARIC program is a large-scale, long-term program that is measuring associations of CHD risk factors with atherosclerosis by race, gender, and geographic location. It focuses on early detection of CVD before symptoms, heart attacks, or strokes occur. The project consists of two groups: a community surveillance component and a cohort component from four communities. Three of the cohort components represent the racial mix of their community, whereas the fourth is exclusively black.

Obligations

Funding History:
   Fiscal Year 2005—$3,340,113
   Fiscal Years 1985–2004—$118,626,131
Total Funding to Date—$121,966,244

Cardiovascular Health Study (CHS), Initiated in Fiscal Year 1988

The CHS is a population-based, longitudinal study of risk factors for the development and progression of CHD and stroke in elderly adults. Specific objectives for this phase of the project include identifying risk association with clinical disease by accumulation of events; determining whether presence or progression of subclinical disease (abnormalities detected noninvasively without signs or symptoms) are better predictors of clinical disease than traditional risk factors; identifying determinants of change in subclinical disease; and identifying characteristics of subgroups at low risk for developing CVD (in whom preventive measures may be unnecessary). Minority representation is sufficient to assess black–white differences.

Obligations

Funding History:
   Fiscal Year 2005—$1,725,937
   Fiscal Years 1988–2004—$74,160,240
Total Funding to Date—$75,886,177

Coronary Artery Risk Development in Young Adults (CARDIA), Initiated in Fiscal Year 1984

The purpose of this study is to increase understanding of contributors to changes in CVD risk factors that occur during the critical years of transition from adolescence through young adulthood to middle age in a cohort of black and white young adults, aged 18 to 30 years in 1985–1986. Currently, CARDIA is addressing questions about lifestyle/psychosocial/socioeconomic risk factors, race, genes, and inflammation in relation to subclinical CVD.

Obligations

Funding History:
   Fiscal Year 2005—$1,266,999
   Fiscal Years 1984–2004—$70,571,397
Total Funding to Date—$71,838,396

DNA Resequencing and Genotyping, Initiated in Fiscal Year 2004

The purpose of this program is to obtain rapid, reliable, and cost-efficient DNA sequencing and genotyping of candidate genomic regions potentially important in the disease pathways of heart, lung, and blood diseases and sleep disorders. This information will assist ongoing investigations of genetic components involved in the causes, variable outcome, and progression of the diseases and disorders.

Obligations

Funding History:
   Fiscal Year 2005—$7,000,000
   Fiscal Year 2004—$4,000,000
Total Funding to Date—$11,000,000

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Framingham Study

The orginal Framingham Study was designed as a longitudinal investigation of constitutional and environmental factors influencing the development of CVD in individuals free of these conditions at the outset. Of the original 5,209 subjects, about 500 members remain alive. In 1971, the Framingham Offspring Study was initiated to assess familial and genetic factors associated with CHD. More than 5,000 offspring (and their spouses) were included. A third-generation cohort consisting of 3,500 grandchildren has been added to permit examination of numerous hypotheses about the familial clustering of CVD and CVD risk factors. Additional goals include identifying new risk factors for cardiovascular, lung, and blood diseases and developing new imaging tests that can detect very early stages of coronary atherosclerosis in otherwise healthy adults.

Obligations

Funding History:
   Fiscal Year 2005—$0
   Fiscal Years 1983–2004—$62,166,638
Total Funding to Date—$62,166,638

Jackson Heart Study (JHS), Initiated in Fiscal Year 1998

The JHS is a single-site epidemiologic study of CVD in blacks, similar to established studies in Framingham, Massachusetts, and Honolulu, Hawaii, with primary goals of identifying risk factors for development and progression of CVD; enhancing recruitment, cohort retention, and scientific productivity of the existing Jackson site of the ARIC study; building research capabilities at minority institutions; developing partnerships between minority and majority institutions; and expanding minority investigator participation in large-scale epidemiologic studies.

Obligations

Funding History:
   Fiscal Year 2005—$5,550,135*
   Fiscal Years 1998–2004—$14,669,854
Total Funding to Date—$20,219,989

Mammalian Genotyping Service (MGS), Initiated in Fiscal Year 1994

The MGS provides genotyping to meritorious projects involving humans, mice, rats, zebrafish, and dogs in all disease areas. It provides genome-wide screens, using short tandem repeat polymorphisms, to assist in finding genes associated with health and disease. Currently, the capacity of the MGS is 7.7 million genotypes per year.

Obligations

Funding History:
   Fiscal Year 2005—$3,749,999
   Fiscal Years 1994–2004—$25,119,750
Total Funding to Date—$28,869,749

Multi-Ethnic Study of Atherosclerosis (MESA), Initiated in Fiscal Year 1999

The purpose of this study is to investigate the prevalence, correlates, and progression of subclinical CVD, i.e., disease detected noninvasively before it has produced clinical signs and symptoms, in a population that is 38 percent white, 28 percent black, 22 percent Hispanic, and 12 percent Asian.

Obligations

Funding History:
   Fiscal Year 2005—$0
   Fiscal Years 1999–2004—$54,269,999
Total Funding to Date—$54,269,999

Pediatric Circulatory Support, Initiated in Fiscal Year 2004

The purpose of this program is to establish multidisciplinary teams to develop innovative circulatory assist devices or other bioengineered systems for infants and children with congenital and acquired CVD who experience cardiopulmonary failure and circulatory collapse.

Obligations

Funding History:
   Fiscal Year 2005—$3,772,658
   Fiscal Year 2004—$4,808,544
Total Funding to Date—$8,581,202

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Proteomics Initiative, Initiated in Fiscal Year 2002

The purpose of this program is to establish highly interactive, multidisciplinary centers to enhance and develop innovative proteomic technologies directed to relevant biologic questions associated with heart, lung, blood, and sleep health and disease. Scientists will focus on the cells’ protein machinery directed toward understanding the molecular basis of the causes and progression of heart, lung, and blood diseases and sleep disorders and identifying targets for therapeutic interventions.

Obligations

Funding History:
   Fiscal Year 2005—$5,896,000
   Fiscal Years 2002–2004—$72,997,890
Total Funding to Date—$78,893,890

Translational Behavioral Science Research Consortium, Initiated in Fiscal Year 2002

The purpose of this program is to establish a consortium of interdisciplinary basic and applied social scientists to conduct research related to developing and testing theories from the behavioral or social sciences concerning cognitive, affective, motivational, developmental, and other factors and processes underlying human behavior. Acquired knowledge will be used to develop and test methods to encourage individuals to adopt and maintain a healthy lifestyle and manage behavioral risk factors for heart, lung, and blood diseases and sleep disorders.

Obligations

Funding History:
   Fiscal Year 2005—$6,117,693
   Fiscal Years 2002–2004—$14,312,876
Total Funding to Date—$20,430,569

Lung Diseases Program

Lung Tissue Research Consortium, Initiated in Fiscal Year 2004

The purpose of this program is to establish a consortium for collecting lung tissues and preparing and distributing them for research. Scientists seek to improve management of lung diseases by increasing understanding of the pathogenetic mechanisms of lung diseases through molecular histopathological studies on tissues with and without disease. Primary emphases are on COPD and idiopathic pulmonary fibrosis.

Obligations

Funding History:
   Fiscal Year 2005—$6,499,999
   Fiscal Year 2004—$3,999,995
Total Funding to Date—$10,499,994

Tuberculosis Curriculum Coordinating Center, Initiated in Fiscal Year 2003

The purpose of this program is to establish a consortium of five Tuberculosis Curriculum Centers to strengthen and increase access to the best ongoing educational and training opportunities in TB for medical, nursing, and allied health schools, especially those that provide primary care to communities where TB is endemic and the population is at high risk.

Obligations

Funding History:
   Fiscal Year 2005—$750,000
   Fiscal Years 2003–2004—$3,000,000
Total Funding to Date—$3,750,000

Blood Diseases and Resources Program

Maintenance of NHLBI Biological Specimen Repository, Initiated in Fiscal Year 1998

The purpose of this project is to establish an NHLBI Biological Specimen Repository for blood specimens from Institute-supported research. The Repository monitors storage, labeling, and testing of the specimens, as well as administers safe shipment of precise sample aliquots to approved investigators for future studies.

Obligations

Funding History:
   Fiscal Year 2005—$990,522
   Fiscal Years 1998–2004—$5,603,820
Total Funding to Date—$6,594,342

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Retrovirus Epidemiology Donor Study (REDS), Initiated in Fiscal Year 1989

This program was established to determine the prevalence of retrovirus positivity in blood donors, a majority of whom are minority. Researchers are evaluating the demographic, risk factor, and behavioral characteristics of blood donors with high risks who continue to donate. A blood specimen repository also is being established as a mechanism for evaluating new tests for known viruses and as a sentinel for as-yet-unrecognized viruses.

Obligations

Funding History:
   Fiscal Year 2005—$13,091,000
   Fiscal Years 1989–2004—$73,774,125
Total Funding to Date—$86,865,125

Sickle Cell Disease Health-Related Quality of Life Questionnaire, Initiated in Fiscal Year 2005

The purpose of this project is to develop a psychometrically sound and clinically useful health-related quality of life instrument and related materials for use in sickle cell clinical trials and outcomes research among adults with SCD, and to assist researchers who are early users of the instrument and materials.

Obligations

Funding History:
   Fiscal Year 2005—$584,008
Total Funding To Date—$584,008

Somatic Cell Therapy Processing Facilities, Initiated in Fiscal Year 2003

This program is designed to develop novel somatic cellular therapies in areas ranging from basic science through animal studies to proof-of-principle and eventually human trials for heart, lung, and blood diseases and sleep disorders. The goal is to provide rapid, safe translation of basic research ideas into clinical practice.

Obligations

Funding History:
   Fiscal Year 2005—$5,841,943
   Fiscal Years 2003–2004—$9,734,266
Total Funding to Date—$15,576,209

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