Types of Research Activity
Research Projects
Research Project Grants (R01): To
support discrete and specific projects to be performed by one or several
investigators in areas of the investigator's particular interests and
competencies.
Research Projects (Cooperative Agreements)
(U01): To support discrete, circumscribed projects in areas of an
investigator's specific interest and competency involving substantial
programmatic participation by the NHLBI during performance of the activity.
Research Program Projects (P01):
To support broadly based, multidisciplinary, often long-term research projects
that have specific major objectives or basic themes directed toward a
well-defined research program goal. Usually, a relatively large, organized
group of researchers conducts individual subprojects, the results of which help
achieve objectives of the program project.
Small Research Grants (R03): To
provide limited support for extended analyses of research data generated by
clinical trials, population research, and demonstration and education
studies.
Academic Research Enhancement Awards (AREA)
(R15): To support small-scale research projects conducted by faculty
in primarily baccalaureate degree-granting domestic institutions. Awards are
for up to $75,000 for direct costs (plus applicable indirect costs) for periods
not to exceed 36 months.
Exploratory/Developmental Grants
(R21): To encourage the development of new research activities in
heart, lung, and blood diseases and sleep disorders program areas.
Resource-Related Research Projects
(R24): To support research projects that will enhance the capability
of resources to serve biomedical research in areas related to cardiovascular,
lung, and blood health and diseases; blood resources; and sleep disorders.
First Independent Research Support and
Transition (FIRST) Award (R29): To provide a sufficient initial period
of research support for newly independent biomedical investigators to develop
their research capabilities and demonstrate the merit of their research
ideas.
Exploratory/Developmental Grant
(R33): To pro- vide phase II support for innovative exploratory and
developmental research activities initiated under the R21 mechanism.
Method To Extend Research in Time (MERIT)
Award (R37): To provide long-term research grant support to
investigators whose research competency and productivity are distinctly
superior and thus are likely to continue to perform in an outstanding manner.
Investigators may not apply for a MERIT award; instead, they are selected by
the NHLBI on the basis of their current grant applications and their present
and past grant support.
Small Business Technology Transfer (STTR)
Grants--Phase I (R41): To support cooperative R&D projects between
small business concerns and research institutions, limited in time and amount,
to establish the technical merit and feasibility of ideas that have potential
for commercialization. Awards are made to small business concerns only.
Small Business Technology Transfer (STTR)
Grants--Phase II (R42): To support in-depth development of cooperative
R&D projects between small business concerns and research institutions,
limited in time and amount, whose feasibility has been established in phase I
and that have potential for commercialization. Awards are made to small
business concerns only.
Small Business Innovation Research (SBIR)
Grants, Phase I (R43): To support projects, limited in time and
amount, to establish the technical merit and feasibility of research and
development ideas that may ultimately lead to commercial products or
services.
Small Business Innovation Research (SBIR)
Grants, Phase II (R44): To support research project ideas that have
been shown to be feasible in phase I and that are likely to result in
commercially marketable products or services.
Research Centers
Exploratory Grants (P20): To
support planning for new programs, expansion or modification of existing
resources, and feasibility studies to explore various approaches to the
development of interdisciplinary programs that offer potential solutions to
problems of special significance to the mission of the NHLBI.
Center Core Grants (P30): To
support shared resources and facilities for basic, clinical, behavioral, and
translational research in the prevention, detection, and treatment of HIV
infection and AIDS.
Animal (Mammalian and Nonmammalian) Model
and Animal and Material Resource Grant (P40): To develop and support
animal models, or animal or biological materials resources. Nonmammalian
resources include nonmammalian vertebrates, invertebrates, cell systems, and
nonbiological systems.
Specialized Centers of Research (SCOR)
Grants (P50): To support both basic and clinical research related to
an Institute-identified theme. The spectrum of SCOR activities comprises
multidisciplinary approaches to specific disease entities or biomedical problem
areas. The SCOR grants differ from research program projects in that they are
in response to an announcement of programmatic needs of the Institute. Centers
may be asked to perform additional studies because of urgently needed
information or may serve as a regional or national resource for special purpose
research.
Comprehensive Specialized Research Center
Grants (U54): To support a large, interrelated biomedical research
program focused on a disorder within the Institute's mandate; to initiate and
expand community education, screening, and counseling programs; and to educate
medical and allied health professionals concerning problems of diagnosis and
treatment of specific diseases such as sickle cell anemia.
Research Career
Programs
Mentored Research Scientist Development
Award for Minority Faculty (K01): To support underrepresented minority
faculty members with varying levels of research experience to prepare them for
research careers as independent investigators.
Mentored Scientist Development Award in
Research Ethics (K01): To provide support for training in research
ethics for health professionals working at academic and other health-related
institutions in biomedical, behavioral, or public health research, particularly
research involving human participants.
Minority Institution Faculty Mentored
Research Scientist Development Award (K01): To support faculty members
at minority institutions who have the interest and potential to conduct
state-of-the-art research in cardiovascular, pulmonary, or hematologic disease,
or in sleep disorders.
Independent Scientist Award (K02):
To enhance the research capability of promising individuals in the formative
stages of their careers of independent research in the sciences related to
heart, lung, and blood diseases; blood resources; and sleep disorders.
Research Career Development Award
(K04): To foster the development of young scientists with outstanding
research potential for careers of independent research in the sciences related
to heart, lung, and blood diseases and blood resources. New grants are no
longer awarded.
Research Career Award (K06): To
assist institutions in supporting established investigators of high competency
for the duration of their careers. New grants are no longer awarded.
Academic Award (K07): To support
an individual with an academic appointment to introduce or improve a disease
curriculum that will enhance the academic or research environment of the
applicant institution as well as further the individual's own career. This
award series includes the Preventive Cardiology Academic Award, the Preventive
Pulmonary Academic Award, the Transfusion Medicine Academic Award, and the
Systemic Pulmonary and Vascular Diseases Academic Awards, the Asthma Academic
Award, the Tuberculosis Academic Award, the Sleep Academic Award, the Nutrition
Academic Award, and the Cultural Competence and Health Disparities Academic
Award. Currently, only the Sleep Academic Award and the Cultural Competence and
Health Disparities Academic Award programs are being supported.
Clinical Investigator Development Award
(K08): To provide an opportunity for clinically trained physicians to
develop research skills and gain experience in advanced research methods and
experimental approaches in basic and applied sciences relevant to
cardiovascular, pulmonary, and hematological diseases. This award was developed
to encourage clinical investigators to engage in research in specific areas
designated by the Institute.
Physician Scientist Award (K11):
To encourage newly trained clinicians to develop independent research
skills and experience in one of the fundamental sciences. New grants are no
longer awarded.
Minority School Faculty Development Award
(K14): To develop faculty investigators at minority schools and to
enhance their research capabilities in areas related to heart, lung, and blood
diseases; blood resources; and sleep disorders. New grants are no longer
awarded.
Research Development Award for Minority
Faculty (K14): To encourage the development of minority faculty
investigators and to enhance their research capabilities in areas related to
cardiovascular, lung, and blood health and disease; transfusion medicine; and
sleep disorders. New grants are no longer awarded.
Career Enhancement Award for Stem Cell
Research (K18): To enable established investigators to acquire new
research capabilities in the use of human or animal embryonic, adult, or cord
blood stem cells. All candidates must have a sponsor, either within their own
or at another institution, who is a well-qualified stem cell expert to serve as
a mentor.
NHLBI Career Transition Award
(K22): To support the postdoctoral research training of an outstanding
individual in an NHLBI intramural laboratory for up to 3 years and
subsequently, to support the individual's successful transition from
postdoctoral research to an extramural environment as an independent
researcher.
Mentored Patient-Oriented Research Career
Development Award (K23): To provide support for career development to
investigators who have made a commitment to focus their research endeavors on
patient- oriented research.
Midcareer Investigator Award in
Patient-Oriented Research (K24): To provide support for clinicians to
allow them "protected time" to devote to patient-oriented research and to act
as mentors for beginning clinical investigators.
Mentored Quantitative Research Career
Development Award (K25): To provide support to investigators with
quantitative science or engineering backgrounds who have made a commitment to
focus their research on basic or clinical biomedicine, bioengineering,
bioimaging, or behavioral sciences.
Clinical Research Curriculum Award (CRCA)
(K30): To stimulate inclusion of high-quality, multidisciplinary
didactic training in fundamental skills, methodology, theories, and
conceptualization as part of the career development of clinical investigators.
Other Research Grants
Scientific Evaluation (R09): To
provide funds to the chairman of an initial review group for operation of the
review group.
Cooperative Clinical Research (R10)
(U10): To support studies and evaluations of relevant clinical
problems. These grants usually involve collaborative efforts among several
institutions and principal investigators and are conducted under a formal
protocol.
Conference Grants (R13): To
support national and international scientific meetings, conferences, or
workshops at which research is discussed.
Research Demonstration and Education
Projects (R18): To provide support designed to develop, test, and
evaluate health-related activities and to foster application of existing
knowledge to the control of heart, lung, and blood diseases and sleep
disorders.
Education Projects (R25): To
provide support for the development and implementation of a program as it
relates to a category in one or more of the areas of education, information,
training, technical assistance, coordination, or evaluation.
Minority Biomedical Research Support Grants
(S06) (S14): To strengthen the biomedical research and research
training capability of minority institutions and to assist in increasing the
involvement of minority faculty and students in biomedical research.
Biomedical Research Support Grants
(S07): To strengthen, balance, and stabilize supported biomedical and
behavioral research programs through flexible funds that permit institutions to
respond quickly and effectively to emerging needs and opportunities; to enhance
creativity and innovation, to support pilot studies, and to improve research
resources.
Continuing Education Training Grant
(T15): To assist professional schools and other public and nonprofit
institutions to establish, expand, or improve programs of continuing
professional education, especially for programs dealing with new scientific
developments.
Scientific Review and Evaluation
(U09): To support an initial Scientific Review Group responsible for
the assessment of scientific and technical merit of grant applications.
Conference (Cooperative Agreements)
(U13): To support international, national, or regional meetings;
conferences; and workshops where substantial programmatic involvement is
planned to assist the recipient.
Resource-Related Research Projects
(U24): To support research projects contributing to improvement of the
capability of resources to serve biomedical research.
National Swine Research and Resource Center
(U42): To support a National Swine Research and Resource Center that
will serve as a resource for depositing, maintaining, preserving, and
distributing swine models for studies of human diseases, as well as
cryopreservation, storage, and reconstitution of embryos and germplasm.
Small Business Innovation Research
Cooperative Agreements (U44): To provide support for phase II and
fast-track projects that directly address identification and preclinical
testing of new therapeutics.
Historical Black College and University
Scientist Award (UH1): To strengthen and augment the human resources
at historically black colleges and universities (HBCU) by recruiting an
established research scientist into their biomedical or behavioral sciences
department; to enhance the career of the recruited research scientist; and to
strengthen other HBCU resources for the conduct of biomedical or behavioral
research in areas related to cardiovascular, lung, and blood health and
disease; transfusion medicine; and sleep disorders.
Individual National
Research Service Awards (NRSA)
Predoctoral Individual NRSA (F31):
To provide predoctoral individuals with supervised research training in areas
related to heart, lung, and blood diseases; blood resources; and sleep
disorders leading toward the research degree (e.g., Ph.D.).
Postdoctoral Individual NRSA (F32):
To provide postdoctoral research training to individuals to broaden
their scientific background and extend their potential for research in areas
related to heart, lung, and blood diseases and blood resources.
NRSA for Senior Fellows (F33): To
provide experienced scientists with an opportunity to make major changes in the
direction of their research careers, to broaden their scientific background, to
acquire new research capabilities, to enlarge their command of an allied
research field, or to take time from regular professional responsibilities for
the purpose of broadening their research capabilities.
Intramural NRSA Individual Postdoctoral
Program Appointee (F35): To offer research health scientists, research
clinicians, and others the opportunity to receive full-time research training
in intramural laboratories of the NHLBI and of other Institutes of the NIH.
Institutional National
Research Service Awards (NRSA)
Institutional NRSA (T32): To
enable institutions to make awards to individuals selected by them for
predoctoral and postdoctoral research training in areas related to heart, lung,
and blood diseases; blood resources; and sleep disorders.
Minority Institutional Research Training
Program (T32M): To support full-time research training for
investigative careers at minority schools in areas of cardiovascular,
pulmonary, and hematologic diseases and sleep disorders. Graduate students,
postdoctoral students, or health professions students may be supported under
this program.
MARC Undergraduate NRSA Institutional
Grants (T34): To support institutional training grants for
underrepresented minority undergraduates to obtain research training and
improve their preparation for graduate training in the biomedical and
behavioral sciences.
NRSA Short-Term Research Training (T35 and
T35S): To provide individuals with research training during
off-quarters or summer periods to encourage research careers or to encourage
research in areas of national need. This program includes the Short-Term
Training for Minority Students Program and short-term training for students in
health professional schools.
MARC Visiting Professors for Minority
Institutions (T36): To increase the number of well-trained minority
scientists in biomedical disciplines and to strengthen the research and
teaching capabilities of minority institutions.
Other Support
Research and Development Contracts
(N01): To develop or apply new knowledge or test, screen, or evaluate
a product, material, device, or component for use by the scientific
community.
Small Business Innovation Research
(N43): To support projects, limited in time and amount, to establish
the technical merit and feasibility of R&D ideas that may ultimately lead
to a commercial product(s) or service(s).
NIH Interagency Agreements (Y01):
To provide a source of funds to another Federal agency to acquire specific
products, services, or studies.
NIH Intra-Agency Agreements (Y02):
To provide a source of funds to another NIH component to acquire specific
products, services, or studies.
Minority Research Supplements
Programs: To provide supplemental funds to active NHLBI grants to
support the research of minority high school, undergraduate, and graduate
students; postdoctoral trainees; and investigators.
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