« Factbook Table of Contents

Types of Research Activity

Research Projects

Research Project Grants (R01): To support discrete and specific projects to be performed by one or several investigators in areas of the investigator's particular interests and competencies.

Research Projects (Cooperative Agreements) (U01): To support discrete, circumscribed projects in areas of an investigator's specific interest and competency involving substantial programmatic participation by the NHLBI during performance of the activity.

Research Program Projects (P01): To support broadly based, multidisciplinary, often long-term research projects that have specific major objectives or basic themes directed toward a well-defined research program goal. Usually, a relatively large, organized group of researchers conducts individual subprojects, the results of which help achieve objectives of the program project.

Small Research Grants (R03): To provide limited support for extended analyses of research data generated by clinical trials, population research, and demonstration and education studies.

Academic Research Enhancement Awards (AREA) (R15): To support small-scale research projects conducted by faculty in primarily baccalaureate degree-granting domestic institutions. Awards are for up to $75,000 for direct costs (plus applicable indirect costs) for periods not to exceed 36 months.

Exploratory/Developmental Grants (R21): To encourage the development of new research activities in heart, lung, and blood diseases and sleep disorders program areas.

Resource-Related Research Projects (R24): To support research projects that will enhance the capability of resources to serve biomedical research in areas related to cardiovascular, lung, and blood health and diseases; blood resources; and sleep disorders.

First Independent Research Support and Transition (FIRST) Award (R29): To provide a sufficient initial period of research support for newly independent biomedical investigators to develop their research capabilities and demonstrate the merit of their research ideas.

Exploratory/Developmental Grant (R33): To pro- vide phase II support for innovative exploratory and developmental research activities initiated under the R21 mechanism.

Method To Extend Research in Time (MERIT) Award (R37): To provide long-term research grant support to investigators whose research competency and productivity are distinctly superior and thus are likely to continue to perform in an outstanding manner. Investigators may not apply for a MERIT award; instead, they are selected by the NHLBI on the basis of their current grant applications and their present and past grant support.

Small Business Technology Transfer (STTR) Grants--Phase I (R41): To support cooperative R&D projects between small business concerns and research institutions, limited in time and amount, to establish the technical merit and feasibility of ideas that have potential for commercialization. Awards are made to small business concerns only.

Small Business Technology Transfer (STTR) Grants--Phase II (R42): To support in-depth development of cooperative R&D projects between small business concerns and research institutions, limited in time and amount, whose feasibility has been established in phase I and that have potential for commercialization. Awards are made to small business concerns only.

Small Business Innovation Research (SBIR) Grants, Phase I (R43): To support projects, limited in time and amount, to establish the technical merit and feasibility of research and development ideas that may ultimately lead to commercial products or services.

Small Business Innovation Research (SBIR) Grants, Phase II (R44): To support research project ideas that have been shown to be feasible in phase I and that are likely to result in commercially marketable products or services.

Research Centers

Exploratory Grants (P20): To support planning for new programs, expansion or modification of existing resources, and feasibility studies to explore various approaches to the development of interdisciplinary programs that offer potential solutions to problems of special significance to the mission of the NHLBI.

Center Core Grants (P30): To support shared resources and facilities for basic, clinical, behavioral, and translational research in the prevention, detection, and treatment of HIV infection and AIDS.

Animal (Mammalian and Nonmammalian) Model and Animal and Material Resource Grant (P40): To develop and support animal models, or animal or biological materials resources. Nonmammalian resources include nonmammalian vertebrates, invertebrates, cell systems, and nonbiological systems.

Specialized Centers of Research (SCOR) Grants (P50): To support both basic and clinical research related to an Institute-identified theme. The spectrum of SCOR activities comprises multidisciplinary approaches to specific disease entities or biomedical problem areas. The SCOR grants differ from research program projects in that they are in response to an announcement of programmatic needs of the Institute. Centers may be asked to perform additional studies because of urgently needed information or may serve as a regional or national resource for special purpose research.

Comprehensive Specialized Research Center Grants (U54): To support a large, interrelated biomedical research program focused on a disorder within the Institute's mandate; to initiate and expand community education, screening, and counseling programs; and to educate medical and allied health professionals concerning problems of diagnosis and treatment of specific diseases such as sickle cell anemia.

Research Career Programs

Mentored Research Scientist Development Award for Minority Faculty (K01): To support underrepresented minority faculty members with varying levels of research experience to prepare them for research careers as independent investigators.

Mentored Scientist Development Award in Research Ethics (K01): To provide support for training in research ethics for health professionals working at academic and other health-related institutions in biomedical, behavioral, or public health research, particularly research involving human participants.

Minority Institution Faculty Mentored Research Scientist Development Award (K01): To support faculty members at minority institutions who have the interest and potential to conduct state-of-the-art research in cardiovascular, pulmonary, or hematologic disease, or in sleep disorders.

Independent Scientist Award (K02): To enhance the research capability of promising individuals in the formative stages of their careers of independent research in the sciences related to heart, lung, and blood diseases; blood resources; and sleep disorders.

Research Career Development Award (K04): To foster the development of young scientists with outstanding research potential for careers of independent research in the sciences related to heart, lung, and blood diseases and blood resources. New grants are no longer awarded.

Research Career Award (K06): To assist institutions in supporting established investigators of high competency for the duration of their careers. New grants are no longer awarded.

Academic Award (K07): To support an individual with an academic appointment to introduce or improve a disease curriculum that will enhance the academic or research environment of the applicant institution as well as further the individual's own career. This award series includes the Preventive Cardiology Academic Award, the Preventive Pulmonary Academic Award, the Transfusion Medicine Academic Award, and the Systemic Pulmonary and Vascular Diseases Academic Awards, the Asthma Academic Award, the Tuberculosis Academic Award, the Sleep Academic Award, the Nutrition Academic Award, and the Cultural Competence and Health Disparities Academic Award. Currently, only the Sleep Academic Award and the Cultural Competence and Health Disparities Academic Award programs are being supported.

Clinical Investigator Development Award (K08): To provide an opportunity for clinically trained physicians to develop research skills and gain experience in advanced research methods and experimental approaches in basic and applied sciences relevant to cardiovascular, pulmonary, and hematological diseases. This award was developed to encourage clinical investigators to engage in research in specific areas designated by the Institute.

Physician Scientist Award (K11): To encourage newly trained clinicians to develop independent research skills and experience in one of the fundamental sciences. New grants are no longer awarded.

Minority School Faculty Development Award (K14): To develop faculty investigators at minority schools and to enhance their research capabilities in areas related to heart, lung, and blood diseases; blood resources; and sleep disorders. New grants are no longer awarded.

Research Development Award for Minority Faculty (K14): To encourage the development of minority faculty investigators and to enhance their research capabilities in areas related to cardiovascular, lung, and blood health and disease; transfusion medicine; and sleep disorders. New grants are no longer awarded.

Career Enhancement Award for Stem Cell Research (K18): To enable established investigators to acquire new research capabilities in the use of human or animal embryonic, adult, or cord blood stem cells. All candidates must have a sponsor, either within their own or at another institution, who is a well-qualified stem cell expert to serve as a mentor.

NHLBI Career Transition Award (K22): To support the postdoctoral research training of an outstanding individual in an NHLBI intramural laboratory for up to 3 years and subsequently, to support the individual's successful transition from postdoctoral research to an extramural environment as an independent researcher.

Mentored Patient-Oriented Research Career Development Award (K23): To provide support for career development to investigators who have made a commitment to focus their research endeavors on patient- oriented research.

Midcareer Investigator Award in Patient-Oriented Research (K24): To provide support for clinicians to allow them "protected time" to devote to patient-oriented research and to act as mentors for beginning clinical investigators.

Mentored Quantitative Research Career Development Award (K25): To provide support to investigators with quantitative science or engineering backgrounds who have made a commitment to focus their research on basic or clinical biomedicine, bioengineering, bioimaging, or behavioral sciences.

Clinical Research Curriculum Award (CRCA) (K30): To stimulate inclusion of high-quality, multidisciplinary didactic training in fundamental skills, methodology, theories, and conceptualization as part of the career development of clinical investigators.

Other Research Grants

Scientific Evaluation (R09): To provide funds to the chairman of an initial review group for operation of the review group.

Cooperative Clinical Research (R10) (U10): To support studies and evaluations of relevant clinical problems. These grants usually involve collaborative efforts among several institutions and principal investigators and are conducted under a formal protocol.

Conference Grants (R13): To support national and international scientific meetings, conferences, or workshops at which research is discussed.

Research Demonstration and Education Projects (R18): To provide support designed to develop, test, and evaluate health-related activities and to foster application of existing knowledge to the control of heart, lung, and blood diseases and sleep disorders.

Education Projects (R25): To provide support for the development and implementation of a program as it relates to a category in one or more of the areas of education, information, training, technical assistance, coordination, or evaluation.

Minority Biomedical Research Support Grants (S06) (S14): To strengthen the biomedical research and research training capability of minority institutions and to assist in increasing the involvement of minority faculty and students in biomedical research.

Biomedical Research Support Grants (S07): To strengthen, balance, and stabilize supported biomedical and behavioral research programs through flexible funds that permit institutions to respond quickly and effectively to emerging needs and opportunities; to enhance creativity and innovation, to support pilot studies, and to improve research resources.

Continuing Education Training Grant (T15): To assist professional schools and other public and nonprofit institutions to establish, expand, or improve programs of continuing professional education, especially for programs dealing with new scientific developments.

Scientific Review and Evaluation (U09): To support an initial Scientific Review Group responsible for the assessment of scientific and technical merit of grant applications.

Conference (Cooperative Agreements) (U13): To support international, national, or regional meetings; conferences; and workshops where substantial programmatic involvement is planned to assist the recipient.

Resource-Related Research Projects (U24): To support research projects contributing to improvement of the capability of resources to serve biomedical research.

National Swine Research and Resource Center (U42): To support a National Swine Research and Resource Center that will serve as a resource for depositing, maintaining, preserving, and distributing swine models for studies of human diseases, as well as cryopreservation, storage, and reconstitution of embryos and germplasm.

Small Business Innovation Research Cooperative Agreements (U44): To provide support for phase II and fast-track projects that directly address identification and preclinical testing of new therapeutics.

Historical Black College and University Scientist Award (UH1): To strengthen and augment the human resources at historically black colleges and universities (HBCU) by recruiting an established research scientist into their biomedical or behavioral sciences department; to enhance the career of the recruited research scientist; and to strengthen other HBCU resources for the conduct of biomedical or behavioral research in areas related to cardiovascular, lung, and blood health and disease; transfusion medicine; and sleep disorders.

Individual National Research Service Awards (NRSA)

Predoctoral Individual NRSA (F31): To provide predoctoral individuals with supervised research training in areas related to heart, lung, and blood diseases; blood resources; and sleep disorders leading toward the research degree (e.g., Ph.D.).

Postdoctoral Individual NRSA (F32): To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in areas related to heart, lung, and blood diseases and blood resources.

NRSA for Senior Fellows (F33): To provide experienced scientists with an opportunity to make major changes in the direction of their research careers, to broaden their scientific background, to acquire new research capabilities, to enlarge their command of an allied research field, or to take time from regular professional responsibilities for the purpose of broadening their research capabilities.

Intramural NRSA Individual Postdoctoral Program Appointee (F35): To offer research health scientists, research clinicians, and others the opportunity to receive full-time research training in intramural laboratories of the NHLBI and of other Institutes of the NIH.

Institutional National Research Service Awards (NRSA)

Institutional NRSA (T32): To enable institutions to make awards to individuals selected by them for predoctoral and postdoctoral research training in areas related to heart, lung, and blood diseases; blood resources; and sleep disorders.

Minority Institutional Research Training Program (T32M): To support full-time research training for investigative careers at minority schools in areas of cardiovascular, pulmonary, and hematologic diseases and sleep disorders. Graduate students, postdoctoral students, or health professions students may be supported under this program.

MARC Undergraduate NRSA Institutional Grants (T34): To support institutional training grants for underrepresented minority undergraduates to obtain research training and improve their preparation for graduate training in the biomedical and behavioral sciences.

NRSA Short-Term Research Training (T35 and T35S): To provide individuals with research training during off-quarters or summer periods to encourage research careers or to encourage research in areas of national need. This program includes the Short-Term Training for Minority Students Program and short-term training for students in health professional schools.

MARC Visiting Professors for Minority Institutions (T36): To increase the number of well-trained minority scientists in biomedical disciplines and to strengthen the research and teaching capabilities of minority institutions.

Other Support

Research and Development Contracts (N01): To develop or apply new knowledge or test, screen, or evaluate a product, material, device, or component for use by the scientific community.

Small Business Innovation Research (N43): To support projects, limited in time and amount, to establish the technical merit and feasibility of R&D ideas that may ultimately lead to a commercial product(s) or service(s).

NIH Interagency Agreements (Y01): To provide a source of funds to another Federal agency to acquire specific products, services, or studies.

NIH Intra-Agency Agreements (Y02): To provide a source of funds to another NIH component to acquire specific products, services, or studies.

Minority Research Supplements Programs: To provide supplemental funds to active NHLBI grants to support the research of minority high school, undergraduate, and graduate students; postdoctoral trainees; and investigators.

« Factbook Table of Contents

Skip footer links and go to content
Twitter iconTwitterExternal link Disclaimer         Facebook iconFacebookimage of external link icon         YouTube iconYouTubeimage of external link icon         Google+ iconGoogle+image of external link icon