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Types of Research Activity

Research Projects

Research Project Grants (R01): To support discrete and specific projects by one or several investigators in areas of the investigator's particular interests and competencies.

Research Projects (Cooperative Agreements) (U01): To support discrete, circumscribed projects in areas of an investigator's specific interest and competency involving substantial programmatic participation by the NHLBI during performance of the activity.

Research Program (Cooperative Agreement) (U19): To support a research program of multiple projects, requiring a broadly-based, multidisciplinary and often long-term approach, directed toward a specific major objective, common theme, or program goal relevant to the Institute's mission. The award involves substantial programmatic involvement by NHLBI staff to assist investigators during performance of the research activities.

Research Program Projects (P01): To support broadly based, multidisciplinary, often long-term research projects that have specific major objectives or basic themes directed toward a well-defined research program goal. Usually, a relatively large, organized group of researchers conducts individual subprojects, the results of which help achieve objectives of the program project.

Small Research Grants (R03): To provide limited support for extended analyses of research data generated by clinical trials, population research, and demonstration and education studies.

Academic Research Enhancement Awards (AREA) (R15): To support small-scale research projects in the biomedical and behavioral sciences conducted by faculty and students at educational institutions that have not been major recipients of NIH research grant funds. Awards are for up to $75,000 for direct costs (plus applicable indirect costs) for periods not to exceed 36 months.

Exploratory/Developmental Grants (R21): To encourage the development of new research activities in heart, lung, and blood diseases and sleep disorders program areas.

Exploratory/Developmental Grant (R33): To pro-vide phase II support for innovative exploratory and developmental research activities initiated under the R21 mechanism.

Clinical Trial Planning Grant (R34): To support pilot studies to obtain data that are critical to the successful design of a full-scale clinical trial.

Method To Extend Research in Time (MERIT) Award (R37): To provide long-term research grant support to investigators whose research competency and productivity are distinctly superior and thus are likely to continue to perform in an outstanding manner. Investigators may not apply for a MERIT award; instead, they are selected by the NHLBI on the basis of their current grant applications and their present and past grant support. As of July 2011, no new nominations for MERIT awards are being made.

Clinical Planning Grant Cooperative Agreement (U34): To support pilot studies to obtain data that are critical to the successful design of a full-scale clinical trial. The award involves substantial programmatic involvement by NHLBI staff to assist investigators during performance of the research activities.

NIH Director's Pioneer Award (DP1): To support individual scientists of exceptional creativity who propose bold and highly innovative approaches that have the potential to produce a major impact on broad, important problems in biomedical and behavioral research.

NIH Director's New Innovator Award (DP2): To support exceptionally creative new investigators who propose highly innovative approaches that have the potential to produce an unusually high impact.

Exploratory/Developmental Cooperative Agreements Phase I (UH2): To support the development of new research activities in program areas that are relevant to the Institute's mission. Support is generally restricted in level of support and in time. The award requires substantial programmatic involvement by NHLBI staff to assist investigators during the performance of research activities.

Multi-Component Research Project Cooperative Agreements (UM1): To support large-scale cooperative agreements that involve complex clinical trials with multiple components (e.g., clinical networks that are relevant to the Institute's mission). The components represent a variety of supporting functions and are not independent of the research projects. The award requires substantial programmatic involvement by NHLBI staff to assist investigators during the performance of research activities.

Small Business Technology Transfer (STTR) Grants Phase I (R41): To support cooperative R&D projects between small business concerns and research institutions, limited in time and amount, to establish the technical merit and feasibility of ideas that have potential for commercialization.

Small Business Technology Transfer (STTR) Grants Phase II (R42): To support in-depth development of cooperative R&D projects between small business concerns and research institutions, limited in time and amount, whose feasibility has been established in phase I and that have potential for commercialization.

Small Business Innovation Research (SBIR) Grants, Phase I (R43): To support projects, limited in time and amount, to establish the technical merit and feasibility of research and development ideas that may ultimately lead to commercial products or services.

Small Business Innovation Research (SBIR) Grants, Phase II (R44): To support research project ideas that have been shown to be feasible in phase I and that are likely to result in commercially marketable products or services.

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Research Centers

Exploratory Grants (P20): To support planning for new programs, expansion or modification of existing resources, and feasibility studies to explore various approaches to the development of interdisciplinary programs that offer potential solutions to problems of special significance to the mission of the NHLBI.

Center Core Grants (P30): To establish research centers to augment research capabilities and resources in biomedical and behavioral research related to heart, lung, blood, and sleep diseases and disorders.

Centers of Research Grants (P50): To accelerate the translation of promising new therapeutic interventions that are derived from fundamental research discoveries to treat and prevent cardiovascular, lung, and blood diseases through planning and executing well-designed clinical trials that demonstrate safety and efficacy.

Specialized Centers of Clinically Oriented Research (SCCOR) Grants (P50): To foster multidisciplinary research on clinically relevant questions enabling basic science findings to be applied more rapidly to clinical problems. Research focuses on clinical and basic scientific issues related to diseases and disorders that are relevant to the mission of the NHLBI. The SCCOR program places more emphasis on clinical research than the SCOR program and requires at least 50 percent of the funded projects to be clinical.

National Swine Research and Resource Center (U42): To support a National Swine Research and Resource Center that will serve as a resource for depositing, maintaining, preserving, and distributing swine models for studies of human diseases, as well as cryopreservation, storage, and reconstitution of embryos and germplasm.

Specialized Centers Grants (U54): To support large, interrelated biomedical research that is focused on a disorder within the Institute's mandate and to enhance the translation of basic research discoveries that could lead to improved prevention, diagnosis, and treatment of thrombotic and hemostatic disorders.

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Research Career Programs

Mentored Career Development Award To Promote Faculty Diversity in Biomedical Research* (K01): To support underrepresented minority faculty members with varying levels of research experience to prepare them for research careers as independent investigators.

Mentored Scientist Development Award in Research Ethics (K01): To provide support for training in research ethics for health professionals working at academic and other health-related institutions in biomedical, behavioral, or public health research, particularly research involving human participants.

Mentored Career Award for Faculty at Minority-Serving Institutions** (K01): To support faculty members at minority institutions who have the interest and potential to conduct state-of-the-art research in cardiovascular, pulmonary, or hematologic disease or in sleep disorders.

Independent Scientist Award (K02): To enhance the research capability of promising individuals in the formative stages of their careers of independent research in sciences related to heart, lung, and blood diseases; blood resources; and sleep disorders.

Academic Award (K07): To support an individual interested in introducing or improving curricula in a particular scientific field as a means of enhancing the educational or research capacity at the grantee institution and the individual's own career. This program includes Academic Awards in Tuberculosis, Sleep, Nutrition, Cultural Competence and Health Disparities, and Pediatric Transfusion Medicine. Currently, the Career Development program is supporting Innovators in Hemoglobinopathies Care.

Clinical Investigator Development Award (K08): To provide an opportunity for clinically trained physicians to develop research skills and gain experience in advanced research methods and experimental approaches in basic and applied sciences relevant to cardiovascular, pulmonary, and hematological diseases and sleep disorders.

Research Career Development Program (K12): To promote comprehensive clinical research training for physicians to prepare them for academic roles in mentoring and leadership in clinical research. The program supports research training in vascular medicine, clinical hematology and transfusion medicine, genetics and genomics of lung diseases, and emergency medicine.

Career Enhancement Award for Stem Cell Research (K18): To enable established investigators to acquire new research capabilities in the use of human or animal embryonic, adult, or cord blood stem cells. All candidates must have a sponsor, either within their own or at another institution, who is a well-qualified stem cell expert to serve as a mentor.

NHLBI Career Transition Award (K22): To support the postdoctoral research training of an outstanding individual in an NHLBI intramural laboratory for up to 3 years and subsequently, to support the individual's successful transition from postdoctoral research to an extramural environment as an independent researcher.

Mentored Patient-Oriented Research Career Development Award (K23): To support the career development of investigators who have made a commitment to focus their research endeavors on patient-oriented research.

Midcareer Investigator Award in Patient-Oriented Research (K24): To provide support for clinicians to allow them protected time to devote to patient-oriented research and to act as mentors for beginning clinical investigators.

Mentored Quantitative Research Career Development Award (K25): To support investigators with quantitative science or engineering backgrounds who have made a commitment to focus their research on basic or clinical biomedicine, bioengineering, bio-imaging, or behavioral sciences.

Pathway to Independence (K99/R00): To provide up to 5 years support in two phases to highly promising postdoctoral scientists to pursue research relevant to the Institute. The K99 phase (Career Transition Award) consists of 1 or 2 years of mentored support, followed by the R00 phase (Research Transition Award) of up to 3 years of independent support, which is contingent on securing an independent research position. Award recipients will be expected to compete successfully for independent research grant support from the NIH or other Institutions during the independence phase to ensure continued support and a smooth transition to independence.

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Other Research Grants

Cooperative Clinical Research (R10) (U10): To support studies and evaluations of relevant clinical problems. These grants usually involve collaborative efforts among several institutions and principal investigators and are conducted under a formal protocol.

Conference Grants (R13): To support national and international scientific meetings, conferences, or workshops at which research is discussed.

Research Demonstration and Education Projects (R18): To support the development, testing, and evaluation of health-related activities and to foster application of existing knowledge to the control of heart, lung, and blood diseases and sleep disorders.

Resource-Related Research Projects (R24): To support research projects that will enhance the capability of resources to serve biomedical research in areas related to cardiovascular, lung, and blood health and diseases; blood resources; and sleep disorders.

Education Projects (R25): To increase the number of students from underrepresented groups in biomedical and behavioral research who complete the Ph.D. degree programs in these fields. The program offers an opportunity to develop new or expand existing effective academic developmental programs, including student research internships, in order to prepare students from underrepresented groups for competitive research careers and leadership positions in the biomedical or behavioral sciences.

Minority Biomedical Research Support Grants (S06):  To strengthen the biomedical research and research training capability of minority institutions and to assist in increasing the involvement of minority faculty and students in biomedical research.

Research Enhancement Award (SC1): To support individual investigator-initiated research projects aimed at developing researchers at minority-serving institutions to a stage where they can transition successfully to other extramural support.

Pilot Project Award (SC2): To support underrepresented minorities who are at the beginning stages of a research career and interested in testing a new idea or generating preliminary data, or who are more experienced investigators and interested in switching to a different field of research.

Continuing Education Training Grant (T15): To assist professional schools and other public and nonprofit institutions to establish, expand, or improve programs of continuing professional education, especially for programs dealing with new scientific developments.

Resource-Related Research Projects (U24): To support research projects contributing to improvement of the capability of resources to serve biomedical research.

Historical Black College and University Scientist Award (UH1): To augment human resources at historically black colleges and universities (HBCU) by recruiting an established research scientist into their biomedical or behavioral sciences department; to enhance the career of the recruited research scientist; and to strengthen other HBCU resources for the conduct of biomedical or behavioral research in areas related to cardiovascular, lung, and blood health and disease; transfusion medicine; and sleep disorders.

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Individual National Research Service Awards (NRSA)

Individual Predoctoral M.D. /Ph.D. NRSA (F30): To provide predoctoral individuals with supervised research training in areas related to heart, lung, and blood diseases; blood resources; and sleep disorders leading toward a combined M.D. /Ph.D. degree. Training under this award is designed to provide a foundation for a career as a physician-scientist in the areas of interest to the NHLBI.

Predoctoral Individual NRSA (F31): To provide predoctoral individuals with supervised research training in areas related to heart, lung, and blood diseases; blood resources; and sleep disorders leading toward the research degree (e.g. , Ph.D. ).

Postdoctoral Individual NRSA (F32): To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in areas related to heart, lung, and blood diseases and blood resources and sleep disorders.

NRSA for Senior Fellows (F33): To provide experienced scientists with an opportunity to make major changes in the direction of their research careers, to broaden their scientific background, to acquire new research capabilities, to enlarge their command of an allied research field, or to take time from regular professional responsibilities for the purpose of broadening their research capabilities.

Institutional National Research Service Awards (NRSA)

Institutional NRSA (T32): To enable institutions to make awards to individuals selected by them for predoctoral and postdoctoral research training in areas related to heart, lung, and blood diseases; blood resources; and sleep disorders.

Minority Institutional Research Training Program (T32M): To support full-time research training for investigative careers at minority schools in areas of cardiovascular, pulmonary, and hematologic diseases and sleep disorders. Graduate students, postdoctoral students, or health professions students may be supported under this program.

MARC Undergraduate NRSA Institutional Grants (T34): To support institutional training grants for underrepresented minority undergraduates to obtain research training and improve their preparation for graduate training in the biomedical and behavioral sciences.

NRSA Short-Term Research Training (T35 and T35M): To provide individuals with research training during off-quarters or summer periods to encourage research careers or to encourage research in areas of national need. This program includes the Short-Term Training for Minority Students Program and short-term training for students in health professional schools.

MARC Visiting Professors for Minority Institutions (T36): To increase the number of well-trained minority scientists in biomedical disciplines and to strengthen the research and teaching capabilities of minority institutions.

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Other Support

Research and Development Contracts (N01): To develop or apply new knowledge or test, screen, or evaluate a product, material, device, or component for use by the scientific community.

Small Business Innovation Research (N43): To support projects, limited in time and amount, to establish the technical merit and feasibility of R&D ideas that may ultimately lead to a commercial product(s) or service(s).

NIH Inter-Agency Agreements (Y01): To provide a source of funds to another Federal Agency to acquire specific products, services, or studies.

NIH Intra-Agency Agreements (Y02): To provide a source of funds to another NIH component to acquire specific products, services, or studies.

Minority Research Supplements Programs: To provide supplemental funds to active NHLBI grants to support the research of minority high school, undergraduate, and graduate students; postdoctoral trainees; and investigators.

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*  Formerly known as Mentored Research Scientist Development Award for Minority Faculty.
** Formerly known as Minority Institution Faculty Mentored Research Scientist Development Award.

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