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Types of Research Activity

Research Projects

Research Project Grants (R01):  To support discrete and specific projects to be performed by one or several investigators in areas of the investigator's particular interests and competencies.

Research Projects (Cooperative Agreements) (U01):  To support discrete, circumscribed projects in areas of an investigator's specific interest and competency involving substantial programmatic participation by the NHLBI during performance of the activity.

Research Program (Cooperative Agreement) (U10):  To support a research program of multiple projects, requiring a broadly-based, multidisciplinary and often long-term approach, directed toward a specific major objective, common theme, or program goal relevant to the Institute's mission.  The award involves substantial programmatic involvement by NHLBI staff to assist investigators during performance of the research activities.

Research Program Projects (P01):  To support broadly based, multidisciplinary, often long-term research projects that have specific major objectives or basic themes directed toward a well-defined research program goal.  Usually, a relatively large, organized group of researchers conducts individual subprojects, the results of which help achieve objectives of the program project.

Small Research Grants (R03):  To provide limited support for extended analyses of research data generated by clinical trials, population research, and demonstration and education studies.

Academic Research Enhancement Awards (AREA) (R15):  To support small-scale research projects conducted by faculty in primarily baccalaureate degree-granting domestic institutions.  Awards are for up to $75,000 for direct costs (plus applicable indirect costs) for periods not to exceed 36 months.

Exploratory/Developmental Grants (R21):  To encourage the development of new research activities in heart, lung, and blood diseases and sleep disorders program areas.

Exploratory/Developmental Grant (R33):  To provide phase II support for innovative exploratory and developmental research activities initiated under the R21 mechanism.

Method To Extend Research in Time (MERIT) Award (R37):  To provide long-term research grant support to investigators whose research competency and productivity are distinctly superior and thus are likely to continue to perform in an outstanding
manner.  Investigators may not apply for a MERIT award; instead, they are selected by the NHLBI on the basis of their current grant applications and their present and past grant support.

NIH Director's Pioneer Award (DP1):  To support individual scientists of exceptional creativity who propose pioneering approaches to major contemporary challenges in biomedical research. 

NIH Director's New Innovator Award (DP2):  To support exceptionally creative new investigators who propose highly innovative approaches that have the potential to produce an unusually high impact.  The New Innovator Award will emphasize the importance and potential impact of the scientific problem, the novelty and innovativeness of the approach, and the applicant's potential for creative and innovative research.

Small Business Technology Transfer (STTR) Grants—Phase I (R41):  To support cooperative R&D projects between small business concerns and research institutions, limited in time and amount, to establish the technical merit and feasibility of ideas that have potential for commercialization.  Awards are made to small business concerns only.

Small Business Technology Transfer (STTR) Grants—Phase II (R42):  To support in-depth development of cooperative R&D projects between small business concerns and research institutions, limited in time and amount, whose feasibility has been established in phase I and that have potential for commercialization.  Awards are made to small business concerns only.

Small Business Innovation Research (SBIR) Grants, Phase I (R43):  To support projects, limited in time and amount, to establish the technical merit and feasibility of research and development ideas that may ultimately lead to commercial products or services.

Small Business Innovation Research (SBIR) Grants, Phase II (R44):  To support research project ideas that have been shown to be feasible in phase I and that are likely to result in commercially marketable products or services.

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Research Centers

Exploratory Grants (P20):  To support planning for new programs, expansion or modification of existing resources, and feasibility studies to explore various approaches to the development of interdisciplinary programs that offer potential solutions to problems of special significance to the mission of the NHLBI.

Center Core Grants (P30):  To support shared resources and facilities for basic, clinical, behavioral, and translational research in the prevention, detection, and treatment of HIV infection and AIDS. 

Animal (Mammalian and Nonmammalian) Model and Animal and Material Resource Grant (P40):  To develop and support animal models, or animal or biological materials resources.  Nonmammalian resources include nonmammalian vertebrates, invertebrates, cell systems, and nonbiological systems.

Specialized Centers of Clinically Oriented Research (SCCOR) Grants (P50):  To foster multidisciplinary research on clinically relevant questions enabling basic science findings to be applied more rapidly to clinical problems.  Research focuses on clinical and basic scientific issues related to diseases and disorders that are relevant to the mission of the NHLBI.  The SCCOR program places more emphasis on clinical research than the SCOR program and requires at least 50 percent of the funded projects to be clinical.

Comprehensive Specialized Research Center Grants (U54):  To support a large, interrelated biomedical research program focused on a disorder within the Institute's mandate; to initiate and expand community education, screening, and counseling programs; and to educate medical and allied health professionals concerning problems of diagnosis and treatment of specific diseases such as sickle cell anemia.

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Research Career Programs

Mentored Research Scientist Development Award for Minority Faculty (K01):  To support underrepresented minority faculty members with varying levels of research experience to prepare them for research careers as independent investigators.

Mentored Scientist Development Award in Research Ethics (K01):  To provide support for training in research ethics for health professionals working at academic and other health-related institutions in biomedical, behavioral, or public health research, particularly research involving human participants.

Minority Institution Faculty Mentored Research Scientist Development Award (K01):  To support faculty members at minority institutions who have the interest and potential to conduct state-of-the-art research in cardiovascular, pulmonary, or hematologic disease or in sleep disorders.

Independent Scientist Award (K02):  To enhance the research capability of promising individuals in the formative stages of their careers of independent research in the sciences related to heart, lung, and blood diseases; blood resources; and sleep disorders.

Research Career Development Award (K04):  To foster the development of young scientists with outstanding research potential for careers of independent research in the sciences related to heart, lung, and blood diseases and blood resources.  New grants are no longer awarded.

Research Career Award (K06):  To assist institutions in supporting established investigators of high competency for the duration of their careers.  New grants are no longer awarded.

Academic Award (K07):  To support an individual with an academic appointment to introduce or improve a disease curriculum that will enhance the academic or research environment of the applicant institution as well as further the individual's own career.  This award series included the Systemic Pulmonary and Vascular Diseases Academic Awards, the Asthma Academic Award, the Tuberculosis Academic Award, the Sleep Academic Award, and the Nutrition Academic Award.  Currently, the Cultural Competence and Health Disparities Academic Award and the Pediatric Transfusion Medicine Academic Award programs are being supported.

Clinical Investigator Development Award (K08):  To provide an opportunity for clinically trained physicians to develop research skills and gain experience in advanced research methods and experimental approaches in basic and applied sciences relevant to cardiovascular, pulmonary, and hematological diseases.

Research Career Development Program in Vascular Medicine (K12):  To promote comprehensive clinical research training for physicians wanting to specialize in vascular medicine.  The goal is to prepare clinicians for academic roles in mentoring and leadership in clinical research in vascular medicine.

Research Career Development Program in Clinical Hematology (K12):  To develop and evaluate multidisciplinary career development programs in clinical hematology research that will equip new academic researchers with the knowledge and skills to address complex problems in blood diseases, transfusion medicine, and cellular therapies.

Research Career Development Program in the Genetics and Genomics of Lung Diseases (K12):  To develop multidisciplinary career development programs in genetics and genomics of lung diseases that will equip new investigators with the knowledge and skills to elucidate the etiology and pathogenesis of such diseases.

Minority School Faculty Development Award (K14):  To develop faculty investigators at minority schools and enhance their research capabilities in areas related to heart, lung, and blood diseases; blood resources; and sleep disorders.  New grants are no longer awarded.

Research Development Award for Minority Faculty (K14):  To encourage the development of minority faculty investigators and enhance their research capabilities in areas related to cardiovascular, lung, and blood health and disease; transfusion medicine; and sleep disorders.  New grants are no longer awarded.

Career Enhancement Award for Stem Cell Research (K18):  To enable established investigators to acquire new research capabilities in the use of human or animal embryonic, adult, or cord blood stem cells.  All candidates must have a sponsor, either within their own or at another institution, who is a well-qualified stem cell expert to serve as a mentor.

NHLBI Career Transition Award (K22):  To support the postdoctoral research training of an outstanding individual in an NHLBI intramural laboratory for up to 3 years and subsequently, to support the individual's successful transition from postdoctoral research to an extramural environment as an independent researcher.

Mentored Patient-Oriented Research Career Development Award (K23):  To provide support for career development to investigators who have made a commitment to focus their research endeavors on patient-oriented research. 

Midcareer Investigator Award in Patient-Oriented Research (K24):  To provide support for clinicians to allow them “protected time” to devote to patient-oriented research and to act as mentors for beginning clinical investigators. 

Mentored Quantitative Research Career Development Award (K25):  To provide support to investigators with quantitative science or engineering backgrounds who have made a commitment to focus their research on basic or clinical biomedicine, bioengineering, bioimaging, or behavioral sciences.

Clinical Research Curriculum Award (CRCA) (K30):  To stimulate inclusion of high-quality, multidisciplinary didactic training in fundamental skills, methodology, theories, and conceptualization as part of the career development of clinical investigators.

Career Transition Award (K99/R00):  To provide up to 5 years support in two phases to highly promising postdoctoral scientists to pursue research relevant to the Institute.  The K99 phase consists of 1 to 2 years mentored support followed by up to 3 years of independent support (R00) contingent on securing an independent research position.  Award recipients will be expected to compete successfully for independent research grant support from the NIH or other Institutions during the independence phase to ensure continued support and a smooth transition to independence.

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Other Research Grants

Scientific Evaluation (R09):  To provide funds to the chairman of an initial review group for operation of the review group.

Cooperative Clinical Research (R10) (U10):  To support studies and evaluations of relevant clinical problems.  These grants usually involve collaborative efforts among several institutions and principal investigators and are conducted under a formal protocol.

Conference Grants (R13):  To support national and international scientific meetings, conferences, or workshops at which research is discussed.

Research Demonstration and Education Projects (R18):  To provide support designed to develop, test, and evaluate health-related activities and to foster application of existing knowledge to the control of heart, lung, and blood diseases and sleep disorders.

Resource-Related Research Projects (R24):  To support research projects that will enhance the capability of resources to serve biomedical research in areas related to cardiovascular, lung, and blood health and diseases; blood resources; and sleep disorders. 

Education Projects (R25):  To provide support for the development and implementation of a program as it relates to a category in one or more of the areas of education, information, training, technical assistance, coordination, or evaluation.

Minority Biomedical Research Support Grants (S06): To strengthen the biomedical research and research training capability of minority institutions and to assist in increasing the involvement of minority faculty and students in biomedical research.

Pilot Project Award (SC2):  To support underrepresentative minorities who are at the beginning stages of a research career and interested in testing a new idea or generating preliminary data, or who are more experienced investigators and interested in switching to a different field of research.

Continuing Education Training Grant (T15):  To assist professional schools and other public and nonprofit institutions to establish, expand, or improve programs of continuing professional education, especially for programs dealing with new scientific developments.

Scientific Review and Evaluation (U09):  To support an initial Scientific Review Group responsible for the assessment of scientific and technical merit of grant applications.

Resource-Related Research Projects (U24):  To support research projects contributing to improvement of the capability of resources to serve biomedical research.

National Swine Research and Resource Center (U42):  To support a National Swine Research and Resource Center that will serve as a resource for depositing, maintaining, preserving, and distributing swine models for studies of human diseases, as well as cryopreservation, storage, and reconstitution of embryos and germplasm.

Historical Black College and University Scientist Award (UH1):  To strengthen and augment the human resources at historically black colleges and universities (HBCU) by recruiting an established research scientist into their biomedical or behavioral sciences department; to enhance the career of the recruited research scientist; and to strengthen other HBCU resources for the conduct of biomedical or behavioral research in areas related to cardiovascular, lung, and blood health and disease; transfusion medicine; and sleep disorders.

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Individual National Research Service Awards (NRSA)

Individual Predoctoral M.D./Ph.D. NRSA (F30):  To provide predoctoral individuals with supervised research training in areas related to heart, lung, and blood diseases; blood resources; sleep disorders leading toward a combined M.D./Ph.D. degree.  Training under this award is designed to provide a foundation for a career as a physician-scientist in the areas of interest to the NHLBI.

Predoctoral Individual NRSA (F31):  To provide predoctoral individuals with supervised research training in areas related to heart, lung, and blood diseases; blood resources; and sleep disorders leading toward the research degree (e.g., Ph.D.).

Postdoctoral Individual NRSA (F32):  To provide postdoctoral research training to individuals to broaden their scientific background and extend their potential for research in areas related to heart, lung, and blood diseases and blood resources.

NRSA for Senior Fellows (F33):  To provide experienced scientists with an opportunity to make major changes in the direction of their research careers, to broaden their scientific background, to acquire new research capabilities, to enlarge their command of an allied research field, or to take time from regular professional responsibilities for the purpose of broadening their research capabilities.

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Institutional National Research Service Awards (NRSA)

Institutional NRSA (T32):  To enable institutions to make awards to individuals selected by them for predoctoral and postdoctoral research training in areas related to heart, lung, and blood diseases; blood resources; and sleep disorders.

Minority Institutional Research Training Program (T32M):  To support full-time research training for investigative careers at minority schools in areas of cardiovascular, pulmonary, and hematologic diseases and sleep disorders.  Graduate students, postdoctoral students, or health professions students may be supported under this program.

MARC Undergraduate NRSA Institutional Grants (T34):  To support institutional training grants for underrepresented minority undergraduates to obtain research training and improve their preparation for graduate training in the biomedical and behavioral sciences.

NRSA Short-Term Research Training (T35 and T35M):  To provide individuals with research training during off-quarters or summer periods to encourage research careers or to encourage research in areas of national need.  This program includes the Short-Term Training for Minority Students Program and short-term training for students in health professional schools.

MARC Visiting Professors for Minority Institutions (T36):  To increase the number of well-trained minority scientists in biomedical disciplines and to strengthen the research and teaching capabilities of minority institutions.

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Other Support

Research and Development Contracts (N01):  To develop or apply new knowledge or test, screen, or evaluate a product, material, device, or component for use by the scientific community.

Small Business Innovation Research (N43):  To support projects, limited in time and amount, to establish the technical merit and feasibility of R&D ideas that may ultimately lead to a commercial product(s) or service(s).

NIH Inter-Agency Agreements (Y01):  To provide a source of funds to another Federal Agency to acquire specific products, services, or studies.

NIH Intra-Agency Agreements (Y02):  To provide a source of funds to another NIH component to acquire specific products, services, or studies.

Minority Research Supplements Programs:  To provide supplemental funds to active NHLBI grants to support the research of minority high school, undergraduate, and graduate students; postdoctoral trainees; and investigators.

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